Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental commencing before the age of 12 years and characterized by developmentally inappropriate inattention, hyperactivity, and/or impulsivity symptoms. Stimulants such as methylphenidate (MPH) are used first-line therapy for children with ADHD. Psychostimulants may be associated vascular problems. Raynaud’s phenomenon (RP) periph...

Carrie D. Patnode, PhD, MPH; Jillian T. Henderson, Erin L. Coppola, Joy Melnikow, MD, Shauna Durbin, Rachel G. Thomas, MPH

Cynthia Feltner, MD, MPH; Ina F. Wallace, PhD; Christine E. Kistler, MASc; Manny Coker-Schwimmer, Daniel Jonas, MPH

BACKGROUND The main aim of this study was to compare the safety and efficacy of IR MPH administered three times daily to those of once daily OROS-MPH. METHODS Subjects were outpatient adults satisfying full diagnostic criteria for DSM-IV ADHD between 19 and 60 years of age. Data from two independently conducted 6-week placebo controlled, randomized clinical trials of IR-MPH (tid) and of OROS-...

dl-Methylphenidate (MPH) has been widely used to treat attention-deficit/hyperactivity disorder (ADHD) for the last half century. It had been exclusively available in the racemic form, i.e., a 50:50 mixture of d- and l-isomers. However, a single enantiomer formulation, d-MPH (dexmethylphenidate), became available for general clinical use in 2002. For this reason, the intrinsic pharmacological d...

Dariush Mozaffarian, MD, DrPH, FAHA; Emelia J. Benjamin, MD, ScM, FAHA; Alan S. Go, MD; Donna K. Arnett, PhD, MSPH, FAHA; Michael J. Blaha, MD, MPH; Mary Cushman, MD, MSc, FAHA; Sandeep R. Das, MD, MPH; Sarah de Ferranti, MD, MPH; Jean-Pierre Després, PhD, FAHA; Heather J. Fullerton, MD, MAS; Virginia J. Howard, PhD, FAHA; Mark D. Huffman, MD, MPH, FAHA; Carmen R. Isasi, MD, PhD; Monik C. Jimén...

Associate Editors Derek C. Angus, MD, MPH, Ethan Basch, MD, Charlene Breedlove, Anne Rentoumis Cappola, MD, ScM, Helene M. Cole, MD, Thomas B. Cole, MD, MPH, W. Gregory Feero, MD, PhD, J. Michael Gaziano, MD, MPH, Donald C. Goff, MD, Preeti N. Malani, MD, MSJ, David H. Mark, MD, MPH, Robert A. McNutt, MD, George T. O’Connor, MD, MS, Boris Pasche, MD, PhD, Eric D. Peterson, MD, MPH, Jeffrey L. S...