BACKGROUND Strains of Staphylococcus aureus with an intermediate level of resistance to vancomycin (vancomycin-intermediate S. aureus, or VISA) or which contain subpopulations of mixed susceptibility (heterogeneous VISA, or hVISA) have been reported worldwide. However, the prevalence of VISA and hVISA infections in Northeast China is unknown. From 2007 through 2010, we surveyed the vancomycin s...

RATIONALE Colonization of lower airways by Staphylococcus aureus is a risk factor for the development of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). However, little is known about the virulence factors of methicillin-sensitive and -resistant S. aureus (MSSA and MRSA) that may influence host colonization and progression to VAT and VAP. OBJECTIVES We...

Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of fatal bacterial infections in hospitals and has become a global health threat. Although the resistance mechanisms of β-lactam antibiotics have been studied for decades, there are few attempts at systems-wide investigations into how the bacteria respond to antibiotic stress. Spectral counting-based label-free quantitative...

BACKGROUND This study aims to investigate the clinical features of invasive community-acquired Staphylococcus aureus (CA-SA) infection in Chinese children and analyze its molecular features. METHODS Clinical data and invasive CA-SA isolates were prospectively collected. Pediatric risk of mortality (PRISM) score was used for disease severity measurement. Molecular typing was then performed, fo...

Methicillin-sensitive and resistant Staphylococcus aureus (MSSA and MRSA, respectively) can cause non-tuberculosis infectious spondylitis. In 43 cases of bacterial infectious spondylitis, Mycobacterium tuberculosis and S. aureus were the two major causative pathogens. MRSA caused more anterior operations and thoracic infections, while MSSA caused more posterior infections and lumbar infections....

Since 1999, a new, epidemic, methicillin-resistant Staphylococcus aureus (MRSA) strain, named the "Cordobes clone," has emerged in Argentina and coexists with the pandemic Brazilian clone. The purpose of this study was to determine the stability over time of the new clone and to investigate its evolutionary relationship with epidemic international MRSA lineages and with other MRSA and methicill...

ObjectivesCefazolin is one of curative treatments for infections due to methicillin-sensitive Staphylococcus aureus (MSSA). Both growth and critical illness may impact the pharmacokinetic (PK) parameters. We aimed build a population PK model cefazolin in critically ill children order optimize individual dosing regimens.MethodsWe included all (age < 18 years, body weight (BW) > 2.5 kg) receiving...

Abstract Objectives To investigate if the addition of cloxacillin to vancomycin enhances activity both monotherapies for treating MSSA and MRSA experimental endocarditis (EE) in rabbits. Methods Vancomycin plus was compared with respective daptomycin. In vitro time–kill studies were performed using standard (105 cfu) high (108 inocula five MRSA, one glycopeptide-intermediate (GISA) strains. One...

background and objectives: staphylococcus aureus is an important cause of nosocomial and community-acquired infections in every region of the world. clindamycin is one of the alternative agents used to treat s. aureus infections and accurate identification of clindamycin resistance is important to prevent therapeutic failure. unfortunately, inducible clindamycin resistance is not detected by st...

Cloxacillin, a semisynthetic penicillin is a potent inhibitor of most penicillinase-producing Staphylococci. Use of high doses of Cloxacillin for 6 weeks is recommended for the treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus (MSSA). Here, we report a case of Cloxacillin-induced agranulocytosis in a patient treated for MSSA native tricuspid valve endoc...