Here, we look at the Sasa-Satsuma equation with M-truncated derivative (SSE-MTD). The analytical solutions in form of trigonometric, hyperbolic, elliptic, and rational functions are constructed using Jacobi elliptic function generalizing Riccati mapping methods. Because Sasa–Satsuma is applied to explain propagation femtosecond pulses optical fibers, acquired can be employed a wide range import...

Recently, Gupta et al. retrospectively evaluated phase I studies of molecularly targeted agents sponsored by the National Cancer Institute’s Cancer Therapy Evaluation Program (NCI-CTEP) (1). They observed a trend for increased response rate (≥61% maximum tolerated dose [MTD] vs ≤60% MTD; odds ratio [OR] = 1.56; P = .10) and statistically significantly improved overall survival (≥61% MTD vs <20%...

BACKGROUND To define a maximum tolerated dose (MTD) for the combination of epirubicin and cyclophosphamide with filgrastim (r-met-HuG-CSF) in patients with advanced solid tumors and non-Hodgkin's lymphoma (NHL). PATIENTS AND METHODS Thirty-five patients with advanced solid tumors were enrolled in stages I and II. Twenty-one patients were treated in stage I in sequential cohorts of at least th...

The basis for current clinical trials in the treatment of colorectal cancer with the combination of irinotecan (CPT-11) and 5-fluorouracil (FUra) with or without leucovorin (LV) is their proven activity as single agents, their different mechanisms of action, and lack of CPT-11 cross-resistance to previous FUra/LV treatment. The role of drug dose and administration sequence in this combination w...

The aim was to investigate interspecies relationships between body weight (W) (kg) and various pharmacokinetic parameters for the anti-tumor agents amsacrine and its 4-methyl-5-(N-methylcarboxamide) analogue, CI-921, and examine which pharmacokinetic parameter, if any, might be used to predict the toxicity of these agents. Pharmacokinetic, plasma protein binding, and toxicity data were availabl...

PURPOSE Vinca alkaloids, agents that cause depolymerization of microtubules, are highly active in treatment of many pediatric cancers. In contrast, taxanes, agents that stabilize microtubules, are far less effective against the same cancer types. The purpose of the current study was to evaluate the antitumor activity of ixabepilone, an epothilone B derivative representing a new class of microtu...

Abstract NCT03522298 was an open-label, multi-center, 2-stage trial designed to establish the maximum tolerated dose (MTD) for once-daily (QD) paxalisib dosing (Stage 1), then evaluate pharmacokinetics(PK) and safety explore efficacy 2). Eligible patients had undergone surgical resection chemoradiotherapy (EORTC 26981–22981/NCIC CE3), a life expectancy of ³ 12 weeks were progression free before...

BACKGROUND An extensive literature has covered the statistical properties of the Continual Reassessment Method (CRM) and the modifications of this method. While there are some applications of CRM designs in recent Phase I trials, the standard method (SM) of escalating doses after three patients with an option for an additional three patients SM remains very popular, mainly due to its simplicity...

Phase I dose-finding studies aim at identifying the maximal tolerated dose (MTD). It is not uncommon that several are conducted, although often with some variation in administration mode or panel. For instance, sorafenib (BAY 43-900) was used as monotherapy least 29 phase trials according to a recent search clinicaltrials.gov. Since toxicity may be directly related specific indication, synthesi...

The dynamics of linear perturbations in a differentially rotating accretion disk with a non-homogeneous vertical structure is investigated. We find that turbulent viscosity results in instability of both pinching oscillations, and bending modes. Not only the low-frequency fundamental modes, but also the high-frequency reflective harmonics appear to be unstable. The question of the limits of app...