A 64-year-old woman with newly diagnosed type 2 diabetes mellitus was admitted with intermittent abdominal pain of 3 years’ duration. Computed tomography (CT) showed multifocal pancreatic cystic lesions with a dilated main pancreatic duct and calcification of a cyst wall (▶Fig. 1), raising suspicion of a mucinous neoplasm of the pancreas. Needle-based confocal laser endomicroscopy (nCLE) (AQ-Fl...

BACKGROUND Pancreatic cystic lesions (PCL) are common. They are increasingly detected as an incidental finding of transabdominal ultrasound or cross-sectional imaging. In contrast to other parenchymal organs, dysontogenetic pancreatic cysts are extremely rare. In symptomatic patients the most frequent PCL are acute and chronic pseudocysts. The majority of incidental cystic lesions, however, are...

BACKGROUND AND AIMS To assess the expression levels of cathepsins in malignant and premalignant lesions. METHODS We retrospectively included patients who underwent pancreatic surgery on pancreatic solid or cystic masses. The expression of cathepsin H, L, B and S was determined in both types of samples. Lesions were divided into three categories: malignant (pancreatic adenocarcinoma and malign...

BACKGROUND The diagnosis of pancreatic cystic neoplasms has become more accurate recently. In some cases, however, doubt remains regarding the lesion's malignant potential. CA 19-9 has long been identified as a reliable biomarker in differentiating pancreatic benign and malignant lesions, especially in non-jaundiced patients. CASE REPORT AND DISCUSSION We report a case of a young female who p...

BACKGROUND Intraductal papillary mucinous neoplasms (IPMN) have been reported to be associated with concurrent, distinct pancreatic ductal adenocarcinoma (con-PDAC) in about 8% (range, 4-10%) of resected branch duct (BD) lesions. In addition, other pancreatic and ampullary tumors are occasionally diagnosed with IPMN in patients undergoing pancreatic surgery. The objective of this study is to de...

BACKGROUND & AIMS Pancreatic intraepithelial neoplasia (PanIN) are pancreatic cancer precursor lesions of unclear origin and significance. PanIN aberrantly express sonic hedgehog (Shh), an initiator of pancreatic cancer, and gastrointestinal mucins. A majority of PanIN are thought to arise from ducts. We identified a novel ductal compartment that is gathered in gland-like outpouches (pancreatic...

Neuroendocrine pancreatic tumours grow slower and metastasise later than ductal and acinar carcinomas. The expression of the p53 tumour suppressor gene in pancreatic neuroendocrine tumour cells is unknown. Pancreatic neuroendocrine cell lines (n = 5) and human tumour tissues (n = 19) were studied for changed p53 coding sequence, transcription, and translation. Proliferative activity of tumour c...

Enteric duplication is an ectopic cyst or a tubular structure composed of smooth muscles surrounding mucosa of the gastrointestinal tract (1). Most cases of duplication are present before the age of 2 years as an acute abdomen or bowel obstruction (2). Diagnosis of duplication cyst is uncommon in adults, and enteric duplication within the pancreas is especially uncommon and difficult to diagnos...

Like other forms of laparoscopic surgery, laparoscopic pancreaticoduodenectomy (Lap-PD) is a minimally invasive procedure that can greatly reduce bleeding during surgery. We performed Lap-PD for a case of intraductal papillary mucinous neoplasm. To remove the resected tissue from the body, we made a small incision directly above the line of transection of the distal pancreas (the cut stump). Th...