Objective To report on the current state of the literature on the genetics of mucoepidermoid and adenoid cystic carcinomas of the salivary glands with a focus on genomic screens and recently discovered genetic translocations. Methods A PubMed based literature review was performed to query for genetics related basic science and preclinical studies about mucoepidermoid and adenoid cystic carcin...

Sialadenoma papilliferum is a rare tumor, primarily of minor salivary gland origin, first described by Abrams and Finck (Cancer 24:1057-63, 1969). It is both an exophytic and endophytic papillary lesion histologically resembling syringocystadenoma papilliferum of sweat gland. The tumor is considered benign although rare recurrent cases have been reported. Three cases of malignant transformation...

OBJECTIVES To report the pathologic findings in cases involving endotracheal and endobronchial tumors in the pediatric population and to describe the presenting symptoms and treatment modalities for endotracheal and endobronchial tumors. DESIGN Retrospective chart review. SETTING Tertiary care children's hospital. PATIENTS The study included 14 patients with endotracheal and endobronchial...

Mena (mammalian Ena) is an actin regulatory protein involved in cell motility and adhesion. Based on its potential role in malignant transformation revealed in other organs, we analyzed the Mena expression in normal salivary glands (SG) and salivary tumors. Mena expression was determined in normal SG (n=10) and also benign (n=20) and malignant (n=35) lesions of SG. For the immunohistochemical s...

Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II-α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, mucoepidermoi...

background: in cancers of prostate, breast, oropharynx, lung, hypopharynx and skin, human tissue kallikreins has been demonstrated as a main role in these problems. there are many research works in which some human tissue kallikreins are expressed in salivary glands. in the present study, the main goal was to determine expression of human tissue kallikreins 4, 8, 10, 11 and 13 in pleomorphic ad...

Introduction: Salivary gland cancer is an uncommon malignancy in the head and neck. The most common histopathologic type salivary malignancies mucoepidermoid carcinoma (MEC). Radiotherapy has a role malignancy, especially inoperable cases postoperative settings. Definitive or radiotherapy with without chemotherapy can improve locoregional control (LRC) patients parotid carcinoma. Case Presentat...

AIMS AND OBJECTIVES This study aims to analyze immunocytochemically p53 aberrant expression and mdm-2 expression in primary and recurrent mucoepidermoid carcinoma (MEC) of parotid gland and to ascertain if expression of these markers correlates with tumor behavior, clinical outcome, histological grade and local recurrence. METHODS 20 cases histologically diagnosed as primary MEC with differen...

Mucoepidermoid carcinoma of the thymus is an extremely rare malignant mediastinal neoplasm, and to our knowledge, only 13 cases have been reported. We report a case of mucoepidermoid carcinoma of the thymus that was seen in a 53-yr-old man with right chest pain. Chest CT scan showed a huge, cystic mass having a focal solid portion with direct invasion of the adjacent anterior chest wall and per...

Estrogen receptors (ERs) expression has been studied in salivary gland tumors, however, there are conflicting results regarding its expression in the literatures. The aim of this study was to investigate the expression of estrogen receptors protein (ERs) in pleomorphic adenoma (PA) and mucoepidermoid carcinoma (MEC) of salivary glands using immunohistochemistry. 35 cases of intraoral minor sali...