Introduction: There are different approaches to reduce the amount of blood loss and allogenic transfusion in cardiac surgery. Regarding this, the present study aimed to evaluate the blood sparing effect of acute normovolemic hemidilution (ANH) combined with intrao-perative tranexamic acid in patients undergoing off-pump coronary artery bypass (OPCAB).Material and Methods: This study was conduct...

The incidence and characteristics of HLA alloimmunization following transfusions of leukocyte concentrates as a source of enzyme replacement were determined in male patients with Hunter's syndrome. Five patients were given leukocyte concentrates from HLA matched donors (Group I) and another five patients received leukocyte concentrates from non-HLA matched donors (Group II). No other blood prod...

Multitransfused recipients of random donor platelet concentrates frequently form broadly-reactive human leukocyte antigen (HLA) antibodies which restrict the pool of suitable donors to those who are HLA matched with the recipient. In an effort to expand the donor pool for such patients, a retrospective analysis of the antibodies formed by alloimmunized recipients was performed taking sensitizat...

BACKGROUND Experimental data have shown that the transfusion of older red blood cell units causes alloimmunization, but the clinical applicability of this statement has never been properly assessed in non-sickle cell patients. It has been hypothesized that older units have higher numbers of cytokines, increasing the risk of alloimmunization related to antigen-presenting events. The goal of this...

AIMS To assess histologically the amount of iron deposited in liver biopsy specimens from HIV positive patients; and to perform estimations of liver iron on tissue from patients with an increase in parenchymal stainable iron. To correlate the amount of blood transfused and the degree of iron overload. METHODS Liver biopsy specimens (n = 120) from 109 HIV positive patients, 74 of whom had AIDS...

Objective: To identify the trends of red cell alloimmunization in multi-transfused females using blood panels.Study design: Cross-sectional study.
 Place and Duration Study: Army Medical College Armed Forces Institute Transfusion with collaboration Pak Emirates Military Hospital, Rawalpindi Pakistan, from Jan to Aug 2018.
 Methodology: Blood samples 75 prior history transfusion were c...

BACKGROUND Increased understanding of the pathophysiology of the acute coagulopathy of trauma has lead many to question the current transfusion approach to hemorrhagic shock. We hypothesized that warm fresh whole blood (WFWB) transfusion would be associated with improved survival in patients with trauma compared with those transfused only stored component therapy (CT). METHODS We retrospectiv...

Background: Thalassemia syndomes are the most common genetic disorder on world wide basis . The selective pressures that have made thalassemias so known but assumed to relate geographic distrubution of malaria. Material & Methods: This was Prospective study conducted in department pediatrics a teriary care hospital. patients who had received m ore than 50 blood transfusions considerd as mul...

Ill babies are more likely to be transfused than any other patients The special care baby unit presents unique problems for the physician caring for ill, newborn infants. These infants, both mature and preterm, are more likely to be transfused with blood products than any other group of patients. The indications for tranfusion and the techniques used by the blood bank to provide for these needs...