The simple, well-understood coordination chemistry of the cyanide ligand is of significant utility in the design of new single-molecule magnets. Its preference for bridging two transition metals in a linear M'-CN-M geometry permits the use of multidentate blocking ligands in directing the assembly of specific molecular architectures. This approach has been employed in the synthesis of numerous ...

A combination of computational and experimental methods was carried out to elucidate the mechanism of palladium-catalyzed water-assisted benzylic C-H amination with N-fluorobenzenesulfonimide (NFSI), which involved the oxidative addition of Pd(II) to Pd(IV)-species as a rate-limiting step, followed by water-assisted concerted metalation-deprotonation (CMD) of the Pd(IV) complex and water-assist...

A photoactivated ruthenium(II) arene complex has been conjugated to two receptor-binding peptides, a dicarba analogue of octreotide and the Arg-Gly-Asp (RGD) tripeptide. These peptides can act as "tumor-targeting devices" since their receptors are overexpressed on the membranes of tumor cells. Both ruthenium-peptide conjugates are stable in aqueous solution in the dark, but upon irradiation wit...

A set of seven caged gadolinium complexes were used as vectors for introducing the chelated Gd(3+) ion into protein crystals in order to provide strong anomalous scattering for de novo phasing. The complexes contained multidentate ligand molecules with different functional groups to provide a panel of possible interactions with the protein. An exhaustive crystallographic analysis showed them to...

Loss of VHR phosphatase causes cell cycle arrest in HeLa carcinoma cells, suggesting that VHR inhibition may be a useful approach to halt the growth of cancer cells. We recently reported that VHR is upregulated in several cervix cancer cell lines as well as in carcinomas of the uterine cervix. Here we report the development of multidentate small-molecule inhibitors of VHR that inhibit its enzym...

The spontaneous adsorption of organic molecules on a variety of planar and nonplanar substrates, that is, self assembly, can generate films just one molecule thick. These nanoscale, self-assembled monolayer (SAM) films have been extensively used to engineer surfaces with well-defined properties. Their utility has been demonstrated in a wide range of applications, including wetting, adhesion, lu...

The design and synthesis of oligomeric ligands based on benzylic thioethers is presented together with their ability to enwrap and stabilize gold nanoparticles with diameters below 2 nm, which become--with increasing length of the oligomer--more monodisperse and stable.

Efficient Light-Emitting Diodes In article number 2205336, Yue-Min Xie, You-Yong Li, Man-Keung Fung, and co-workers introduce a novel multidentate molecule (Formamidine Sulfinic Acid, FSA) to heal perovskite defects, where the intense bonding strength of ?S?O –NH2 groups undercoordinated Pb defects can effectively facilitate passivation perovskites, thus leading modified crystallization propert...