نتایج جستجو برای: multidrug resistant tuberculosis
تعداد نتایج: 291703 فیلتر نتایج به سال:
There has been considerable interest in various analogues of antitubercular drugs particularly against multidrug and extensively drug resistant tuberculosis because mycobacterium species has developed resistant against available drugs. The currently used antitubercular also causes some serious toxic effects and also require long period of therapy for the treatment. Therefore, various new drugs ...
Introduction: The incidence of multidrug resistant tuberculosis is increasing in developing countries. Aminoglycosides are an integral part of second-line drugs, however ototoxicity is a major limitation for their use. This study aims to determine the extent of hearing loss in patients taking one of the commonly prescribed drugs for Multidrug resistant tuberculosis (MDR-TB), Kanamycin, at a Gov...
We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-resistant tuberculosis when treatment options are limited.
We found high prevalence rates of multidrug-resistant tuberculosis among retreatment patients (71.1%) and persons with new cases (8.0%) in Angola. These findings are of concern but should be interpreted with caution. A national drug-resistance survey is urgently needed to determine the actual prevalence of multidrug-resistant tuberculosis in Angola.
OBJECTIVE This study sought to determine the impact of the World Health Organization's directly observed treatment strategy (DOTS) compared with that of DOTS-plus on tuberculosis deaths, mainly in the developing world. DESIGN Decision analysis with Monte Carlo simulation of a Markov decision tree. DATA SOURCES People with smear positive pulmonary tuberculosis. DATA ANALYSIS Analyses model...
Children exposed to multidrug-resistant (MDR) Mycobacterium tuberculosis are at risk of developing MDR tuberculosis. Where treatment is available, it is lengthy, expensive, and associated with poor adherence and notable morbidity and mortality. Preventive treatment effectively lowers the risk of disease progression for contacts of individuals with drug-susceptible tuberculosis, but this strateg...
Multidrug-resistant tuberculosis (MDR-TB), defined as being resistant to at least rifampicin and isoniazid, has an increasing burden and threatens TB control. Diagnosis is limited and usually delayed while treatment is long lasting, toxic and poorly effective. MDR-TB management in scarce-resource settings is demanding however it is feasible and extremely necessary. In these settings, cure rates...
Two new drugs-bedaquiline and delamanid-have recently been approved by stringent regulatory authorities to treat multidrug-resistant tuberculosis (TB) and recommended by the World Health Organization for use under defined programmatic conditions. Introducing the medications in TB programs worldwide has not kept pace with the need for these drugs. In response, the DR-TB STAT (Drug-Resistant TB S...
The magnitude of problem with tuberculosis lies in the fact that one third of the world population is infected by Mycobacterium tuberculosis. Even in the 21st century, tuberculosis kills more people than any other infective agent. Definition of case of resistance--the case of resistant tuberculosis is precisely defined by the recommendations of the World Health Organization as primary, initial,...
Tuberculosis is a highly infectious disease. It usually infects the lung, but dissemination to different organs results in severe form of tuberculosis, i.e., disseminated tuberculosis. The situation becomes even more challenging when infection due multidrug-resistant strains Mycobacterium present case very rare one where 17-year-old Indian girl presented with headache, vomiting, cough expectora...
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