A sample of 200 patients who had been treated for alcoholism in a multimodal inpatient program that used aversion therapy as a treatment component was selected for outcome evaluation. One hundred sixty (80%) were located. A minimum of 13 months had elapsed since treatment (mean 20.5 months) collateral reports were used to verify self-reports in 36% of the cases. Abstinence status was determined...

Penile squamous cell carcinoma (pSCC) is a rare disease, making it difficult to establish a standard of care, particularly in the advanced stage. We report a case of pSCC with advanced lymph node metastasis treated with multimodal therapy consisting of combination chemotherapy, irradiation, and chemosurgery using Mohs' zinc chloride-containing paste. An 80-year-old male with a past history of l...

Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative and palliative intention in numerous clinical situations from precursor lesions such as ductal carcinoma in situ (DCIS) to advanced breast cancer. This review addresses current controversial...

The treatment of pancreatic carcinoma remains one of the most formidable challenges in oncology. Curative resection, currently the only available treatment option, provides no significant impact on long-term survival. The recent development of multimodal treatment options for pancreatic cancer has provided clinical benefits and improved patient survival. In this study, we retrospectively evalua...

numerous algorithms have been proposed to solve the shortest-pathproblem; many of them consider a single-mode network and crispcosts. other attempts have addressed the problem of fuzzy costs ina single-mode network, the so-called fuzzy shortest-path problem(fspp). the main contribution of the present work is to solve theoptimum path problem in a multimodal transportation network, inwhich the co...

abstractthe aim of intercultural translation is to communicate. communication is acted via verbal as well as visual means. the interaction of verbal and visual means of communication makes a set of complex situations which demand special attention in translation. one context in which the interaction of visual and verbal elements gets vital importance is children’s picture books. color is an int...

The literature describes multimodal pain-management programs as successful therapy options in the conservative treatment of chronic low back pain. Yet, the intensity and inclusion criteria of such programs remain debatable. In many studies, the pain originating from spinal structures is described as nonspecific low back pain - a diffuse diagnosis without serious implications. The purpose of thi...

Recently, nonoperative treatment such as chemotherapy or radiotherapy has commonly been performed for submucosal carcinoma of the esophagus. Although endoscopic mucosal resection1)2) (EMR) or endoscopic submucosal dissection3) (ESD) is usually done as curative treatment for mucosal cancer of the esophagus, the efficacy of multimodal therapy combined with EMR/ESD for esophageal squamous cell car...

BACKGROUND Radical esophagectomy with lymphadenectomy remains the only curative therapy for patients with resectable esophageal squamous cell cancer (ESCC), however, combined treatment modalities may improve survival. Based upon more than 1300 consecutive esophageal resections, we present our current multidisciplinary ESCC approach with analysis in the context of recently published RCTs. METH...

A semi-analytical method is used to illustrate the behavior of a multimodal nonlinear electromechanical system which is under base-excitation. System is considered as piezo-ceramic patches attached to a cantilever beam coupled to a resistive load. The cantilever beam is modeled as a nonlinear Timoshenko beam using Assumed Mode method and equations of motion are derived through Lagrange's equati...