Objective We describe a case of bilateral sequential optic neuropathies with pachymeningitis and aortitis, findings that raised suspicion Erdheim-Chester disease versus IgG-4 related disease. Background (ECD) is rare histiocytic neoplasm characterized by tissue infiltration foamy histiocytes, chronic, uncontrolled inflammation. IgG4-related (IgG4-RD) an insidiously progressive immune-mediated f...

Giant fusiform basilar aneurysms (dolicho-ectatic basilar anomalies) are rare and have not previously been reported to cause embolic infarction in territory distal to the aneurysm. They most commonly present as posterior fossa mass lesions with brainstem compression and cranial neuropathies. Originally considered atherosclerotic in etiology, recent authors feel that they may represent a unique ...

Metastatic tumors in the sellar and parasellar regions are uncommon and rarely detected in clinical practice. We present four cases of sellar and parasellar metastatic tumors, which metastasized from distant organ in one case and extended directly from adjacent structures in three. Common presenting symptoms were cranial neuropathies, headache and facial pain. Invasion into the cavernous sinus ...

how to cite this article: talebian a, goudarzi rm, mohammadzadeh m , mirzadeh as. vincristine-induced cranial neuropathy. iran j child neurol. 2014 winter; 8(1):66-68.   abstract vincristine (vcr) is a vinca alkaloid that is used for treatment of many malignancies. the vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects.  de...

Dear Sir, Lyme disease, caused by the spirochete Borrelia burgdorferi, is a tick‐borne disease, the global distribution of which corresponds to the distribution of Ixodes tick that transmits the organism.[1] Although very commonly reported from the temperate regions of the world, the incidence has increased worldwide due to increasing travel and changing habitats of the vector. Neuroborreliosis...

IgG4-related disease is a fibro-inflammatory condition with tendency to form tumors with inflammatory infiltrate with IgG4 rich plasma cells and elevation of IgG4 level in serum, which may affect virtually every organ and tissue in the organism. IgG4-related ophthalmic disease may present as dacryoadenitis, myositis, other orbital tissues, hypophysitis or pachymeningitis causing cranial neuropa...

We report a case of relapsing multifocal neurological disease associated with CNS echovirus 6 infection in an HIV-1-infected individual with no evidence of immunoglobulin deficiency. The illness was initially characterized by optic and cranial neuropathies and myelopathy; concurrent granulomatous hepatitis suggested disseminated viral infection. Treatment with combination nucleoside analogues l...

A modified technique for performing Amipaque myelocisternography is described and results obtained in the first 100 patients are analyzed. Diagnostic quality examinations were obtained in 90% of patients in whom the technique was employed. The complication rate was comparable to studies using C1-C2 puncture and to other reports using Amipaque contrast medium. This examination is valuable for hi...