نتایج جستجو برای: multiple doses
تعداد نتایج: 857615 فیلتر نتایج به سال:
BACKGROUND Mitochondrial disorders are a clinically, biochemically and genetically heterogeneous group of multi-system diseases, with an unmet medical need for treatment. KH176 is an orally bio-available small molecule under development for the treatment of mitochondrial(-related) diseases. The compound is a member of a new class of drugs, acting as a potent intracellular redox-modulating agent...
Methotrexate may cause seizures, dementia, and leukoencephalopathy when given in toxic doses to children with leukemia or solid tumors. Even in therapeutic doses, treatment with this drug is associated with an increased incidence of seizures in children with leukemia. To study mechanisms of injury, juvenile rats were given multiple intraventricular injections of methotrexate and the brains were...
BACKGROUND Patients consider multiple parameters in adjusting prandial insulin doses for optimal glycemic control. Difficulties in calculations can lead to incorrect doses or induce patients to administer fixed doses, rely on empirical estimates, or skip boluses. METHOD A multicenter study was conducted with 205 diabetes subjects who were on multiple daily injections of rapid/ short-acting in...
BACKGROUND Food allergy is the most common cause of anaphylaxis outside the hospital setting. OBJECTIVE We sought to determine the rate, circumstances, and risk factors for repeated doses of epinephrine in the treatment of food-induced anaphylaxis in children. METHODS Anonymous questionnaires were distributed to families of children with food allergies during allergy outpatient visits to a ...
The pharmacokinetics and safety of ceftolozane, a novel cephalosporin, and tazobactam, a β-lactamase inhibitor, alone and in combination as a 2:1 ratio in single doses of up to 2,000 and 1,000 mg of ceftolozane and tazobactam, respectively, and multiple doses of up to 3,000 and 1,500 mg of ceftolozane and tazobactam, respectively, per day were evaluated in healthy adult subjects. In part 1, gro...
there is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. we prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...
background: a substantial part of the public’s natural radiation dose is due to the inhalation of radon gas. most of the exposure occurs indoors where the airborne concentration of radon and its decay products is usually higher than outdoors. materials and methods: radon activity concentration has been measured twice in 50 classrooms in 5 levels (10 each) during summer and winter using solid-st...
BACKGROUND Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL) but the appropriate single dose is unknown. METHODOLOGY A multi-centre, open-label, non-inferiority, randomized controlled trial with an adaptive design, was conducted to compare the efficacy and safety of a single dose and m...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید