background:  multiple  sclerosis  (ms) is a  chronic inflammatory  demyelinating  and  neurodegenerative disease  of central  nervous  system  with unknown  causes. etiology of ms involves  both  genetic  and  environment factors.  the  interleukin  7   receptor   (il7r)   gene   is  a promising candidate  for ms, because its involvement in the autoimmunity, regulation of the t-cell homeostasis...

Classification approaches have been increasingly applied to differentiate patients and normal controls using resting-state functional magnetic resonance imaging data (RS-fMRI). Although most previous classification studies have reported promising accuracy within individual datasets, achieving high levels of accuracy with multiple datasets remains challenging for two main reasons: high dimension...

abstract background: fatigue is the most common and highly disabling symptom of multiple sclerosis (ms) that has negative effects on employment, the process of socialization, compliance with the disease, and other factors effective on activities of daily living. the usage of complementary and alternative medicine methods in ms patients is higher than in the general population. however, there is...

background: mesenchymal stem cells (mscs) with their potential to differentiate into mesodermal and non-mesodermal lineages have several immunomodulatory characteris-tics. these properties make them promising tools in cell and gene therapy. objective: to evaluate the potential therapeutic applications of autologous msc in improving clinical manifestations of ms patients. methods: ten patients w...

multiple sclerosis (ms) and migraine are two common neurological disorders affecting women more than men. sleep quality impairment has been reported in both diseases. the goal of this study was to compare sleep quality and depression between women with ms and migraine. seventy women with migraine and 75 women with ms were enrolled in this study. participants were asked to fill-out valid and rel...

none of the approved immunomodulatory drugs in adults multiple sclerosis (ms) patients have been officially approved for the pediatric patients and are currently used off-label in this population. in this study, we evaluated the effectiveness and tolerability of intramuscular interferon beta1-a (avonex®) and subcutaneously injected interferon beta1-b (betaferon®) in children with definite relap...

conclusions orem’s self-care model is significantly effective in reducing the fatigue of multiple sclerosis patients. objectives to determining the effect of orem’s self-care model on fatigue in multiple sclerosis patients. patients and methods this research involved a clinical trial. sixty-three multiple sclerosis patients at the vice-chancellor in treatment affairs of yasuj university of medi...