Type I diabetes (T1D) is an autoimmune disease resulting in gradual cell-mediated destruction of insulin producing beta cells in the pancreatic islets of Langerhans. The most plausible environmental triggers to launch and/or accelerate this process in a genetically predisposed organism include enterovirus infections and oxidative stress. Among other enteroviruses the group B of coxsackieviruses...

at many circumstances, in heat exchange processes several exchangers were used with different cost laws due to their pressure ratings, materials of construction and exchange3r types. in such circumstances traditional methods of pinch technology can not be led to minimum total annual cost may cause some other disadvantages like more complexity or higher maintenance. in this research work a new a...

Engineered nanoparticles (eNPs) for biological and biomedical applications are produced from functionalised nanoparticles (NPs) after undergoing multiple handling steps, giving rise to an inevitable loss of NPs. Herein we present a practical method to quantify nanoparticles (NPs) number per volume in an aqueous suspension using standard spectrophotometers and minute amounts of the suspensions (...

objective: group a rotaviruses (garv) are responsible for the vast majority of severe diarrhea worldwide that kills an estimated 600,000-870,000 children annually. since infantile gastroenteritis is a main health problem, therefore diagnosis and treatment of this disease is crucial. gene rearrangements have been detected in vitro during serial passages of the virus at a high multiplicity of inf...

Nonviable, 5-iodouracil (IUra)-substituted bacteriophage T4td8 can be multiplicity reactivated. The data indicate that two nonviable, IUra-substituted T4td8 phage can complement each other intracellularly to produce viable progeny. Phage particles in lysates of T4td8-infected Escherichia coli BT(-), prepared in the presence of varying mole fractions of IUra plus thymine, were examined by infect...

Pseudomonas aeruginosa, an opportunistic pathogen responsible most notably for severe infections in cystic fibrosis (CF) patients, utilizes the type III secretion system for eukaryotic cell intoxication. The CF clinical isolate CHA shows toxicity towards human polymorphonuclear neutrophils (PMNs) which is dependent on the type III secretion system but independent of the cytotoxin ExoU. In the p...

Ultraviolet light (UV) impaired the capacity of L cells to support growth of encephalomyocarditis virus. The loss of capacity was partially restored by high multiplicity of infection (MOI). This phenomenon was not due to an increased probability of an infectious virus particle reaching a site of replication undamaged by UV, since UV-inactivated virus at high MOI induced restoration of the capac...

Bluetongue virus (BTV) infection effectively activates the innate immune response, followed by expression of interferon (IFN) and multiple interferon-stimulated genes (ISGs). ISG15 is one most induced ISGs, often plays a role in inhibiting replication. This study aims to explore specific mechanisms ovine (oISG15) BTV infection. We found that transcription level oISG15 was upregulated time-depen...