multi-drug therapy in high blood pressure is appreciated to achieve a normalblood pressure.a simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (amd) and metoprolol(met) in pharmacutical preparations. calibration matrix contains 3.402 µgml -1 to 170.130 µgml -1 and from 13.060 µgml -1 to 65.3 µgml -1 amlodipine a...

A rapid method for the quantitative determination of iodine value (IV) and acid value (AV) of red fruit oil (RFO) using FTIR spectroscopy and multivariate calibration of partial least square (PLS) is described. A calibration standard was developed using a series of RFO subjected to thermal treatment at without heating (ambient temperature); 100oC, 150oC, 180oC, 200oC and 300oC, respectively. Ba...

Background: Two simple, precise and accurate multivariate calibration methods, partial least square (PLS) and principal component regression (PCR) have been applied for the simultaneous determination and dissolution profile evaluation of atorvastatin (ATV) and ezetimibe (EZT) in their binary mixtures and commercial tablets. Due to the closely overlapping spectral bands of the mentioned drugs, s...

Smoldering fires are characterized by the production of early gas emissions that can include high levels CO and Volatile Organic Compounds (VOCs) due to pyrolysis or thermal degradation. Nowadays, standalone sensors, smoke detectors, a combination these, standard components for fire alarm systems. While sensor arrays together with pattern recognition techniques valuable alternative detection, i...

a new fourier transform-infra red (ft-ir) spectrometric method was developed for assaying hydrochlorothiazide (hct) and enalapril maleate (enm) in binary solid pharmaceutical formulations. multivariate partial least squares (pls) method was used for calibration of derivative spectral data. acetonitrile was used as solvent due to its spectral transparency and adequate solubility of analytes in i...