See Article, pages 860–872 More than 20 years ago, a new secreted ligand of the tumor necrosis factor (TNF) family was identified in mouse peritoneal macrophages, human tonsils and fetal liver. However, contrast to TNF, TWEAK induced only slightly apoptosis panel cell types including hematopoietic cells, fibroblasts cancer thus named for “Tumor factor-like WEAK inducer apoptosis”. There are 2 f...

Earth's Future thanks its reviewers who contributed in 2022 In this article, we are delighted to publish the names of 780 peer submitted reviews (italicized have 3 or more reviews). We express our deep appreciation for your thoughtful comments and suggestions on manuscripts Future. Your scholarly assessments were fundamental decisions, significantly improved quality published papers. As a trans...

Abstract In this article, we explore some of the barriers that prevent learning about grand challenges. By challenges, refer to transformational social and environmental issues critical toward addressing them. Despite recent research contributions, initiatives, calls for action focus on such concerns, relatively little is known different hinder To these issues, draw from Rayner’s (2012) concept...

•Axon regeneration after spinal cord injury requires recruitment of pdgfrb+ cells•PDGFR signaling controls cell to the lesion site•pdgfrb+ cells secrete axon growth-promoting ECM molecules (cthrc1a and col12a1a/b)•pdgfrb+ reduce synthesis (lum mfap2) that inhibit growth In mammals, perivascular cell-derived scarring impedes axonal regrowth. contrast, extracellular matrix (ECM) in site zebrafish...

•Interfacial halogen-halogen bonds are introduced in 2D/3D hybrid perovskite•Interfacial suppress phase separation•Mixed halogen perovskite devices achieve long-term operational stability Perovskite-silicon tandem photovoltaics represent the most promising next-generation photovoltaic technology and could revolutionize current silicon-based technology. However, lifetimes of perovskite-silicon s...

•MP31 is a micropeptide encoded from 5? UTR of PTEN•MP31 localizes in mitochondria and limits lactate-pyruvate conversion•MP31 loss promotes lactate metabolism OXPHOS glioblastoma•Recombinant MP31 has therapeutic effects on GBM mice model without inducing toxicity The metabolic role micropeptides generated untranslated regions remains unclear. Here we describe MP31, by the upstream open reading...

The ability to recognize the concept of early numbers in childhood is very important develop so that children are ready take part learning mathematics at a higher level. This study aims determine effect approaches and self-regulation kindergarten. used an experimental method with treatment design by level 2x2. sample was 32 children. Score data, number concepts, analyzed interpreted. results sh...

The susceptibility of Atlantic cod (Gadus morhua) and Atlantic Halibut (Hippoglossus hippoglossus) to an Atlantic salmon (Salmo salar) pathogenic isolate of infectious salmon anaemia was investigated. No mortality or clinical signs of infectious salmon anaemia disease were recorded in either species following experimental challenge via intra-peritoneal (i.p.) injection or cohabitation with i.p....

Lemon grass a popular aromatic plant which is commonly used as a substitute of green tea has a tremendous phytomedicinal potential. Like other tea plants it also having antimicrobial as well as antiprotozoal potential. Main objective of the present study was to find out the anthelmintic potential of aqueous extract of Cymbopogon citratus (lemon grass) by using a model worm i.e. Pheretima posthu...

Differential profiles of language impairments in genetic developmental disorders have been argued to reveal the component parts of the language system and perhaps even the genetic specification of those components. Focusing predominantly on a comparison between Williams syndrome and Specific Language Impairment, we argue that the detailed level of behavioural fractionations observed in these di...