Symptomatic neuromas are an all-too-common complication following limb amputation or extremity trauma, leading to chronic and debilitating pain for patients. Surgical resection of symptomatic has proven be the superior method intervention, but traditional methods neuroma do not address underlying pathophysiology formation a future lead high reoperation rates. Novel approaches employ physiology ...

Recall that variation distance is defined as ‖μ− ξ‖ = 12 ∑ x∈Ω |μ(x)− ξ(x)| = maxA⊂Ω |μ(A)− ξ(A)|. Recall also that for any t > τmix · dln −1e we have ∆(t) ≤ . In general, our goal was to randomly sample elements of a large set Ω from a distribution defined implicitly by assigning a positive weight w(x) to each x ∈ Ω and then normalizing. So, Pr[x is choosen] = w(x) Z where Z = ∑ x∈Ω w(x). Howe...