BACKGROUND AND OBJECTIVES The immunoglobulin VH gene mutation status is a strong prognostic indicator in B-cell chronic lymphocytic leukemia (CLL), since unmutated VH genes are correlated with short survival. However, the traditional cut-off level dividing mutated and unmutated cases, i.e. more or less than 2% mutations, has been questioned and other cut-offs have been suggested. We investigate...

Hidradenitis Suppurativa (HS) is an inflammatory skin disease started by hair follicle epithelial stem cells that proliferate in uncontrolled manner, forming a keratin plug the and interconnected tendrils dermis. These processes are accompanied infiltration of neutrophils Th17 HS lesions. Mutations NCSTN gene have been associated with HS, but lack vitro models for pilosebaceous unit hinders stu...

Tumor tissue explants are an attractive tool for personalized predictive tests, however their use is compromised by subjective nature of morphological assessment drug response. We aimed to identify reporter genes, which rapidly change level expression in drug-sensitive but not drug-resistant tumors. Fresh tumor tissues were obtained from patients with non-small cell lung cancer (NSCLC) undergoi...

Aicardi-Goutieres syndrome (AGS) is an inflammatory genetic disease inherited in an autosomal recessive manner. Common features of this disease are encephalopathy, splenomegaly and hepatomegaly, muscle stiffness, irritability, unstoppable crying, seizures and dilation in growth. According to previous studies, primary genes responsible for this Syndromes are as followed: TREX 1, RNASEH2A, RNASEH...

P53 is one of the gene that has important role in human cell cycle and in the human cancers too.Models of codon substitution make it possible to separate mutational biases in the DNA fromselective constraints on the protein, and offer a great advantage over amino acid models forunderstanding the evolutionary process of proteins and protein-coding DNA sequences. In thiswork, we investigated abou...