BACKGROUND The diagnosis of cardiac necrosis such as myocardial infarction can be difficult and relies on the use of circulating protein markers like troponin. However, there is a clear need to identify circulating, specific biomarkers that can detect cardiac ischemia without necrosis. METHODS AND RESULTS Using specific immunoassay and tandem mass spectrometry, we show that a fragment derived...

Acute myocardial infarction is the major cause of death and disability worldwide, with an ongoing increase in incidence every year. Therefore, diagnosis of acute myocardial infarction should be made early and accurately to decrease the associated mortality and morbidity. The current gold standard cardiac biomarkers (Troponin and CKMB) for rapid rule in and rule out for acute myocardial infarcti...

Traditional circulating biomarkers play a fundamental role in the diagnosis and prognosis of acute myocardial infarction (AMI). However, they have several limitations. microRNAs (miRs), a class of RNA molecules that do not encode proteins, function directly at the RNA level by inhibiting the translation of messenger RNAs. Due to their significant roles in disease development, they can be used a...

Introduction: Recent studies have shown that myocardial T1 after administration of an extracellular Gd-based contrast agent and the myocardial partition coefficient represent novel biomarkers of diffuse fibrosis, which may be not recognized by standard methods for imaging delayed contrast enhancement [1-2]. Such novel markers of diffuse fibrosis and remodeling of the extracellular matrix could ...

conclusions an adjuvant therapy with tlc diet and supplementation with q10 and lc seems to be required for secondary prevention following mi and pci. tlc diet and q10 plus lc appeared to be effective in inflammatory biomarkers of isr as well as ldl reduction. methods this single-blind randomized controlled trial was conducted on 128 subjects. after randomization for treatment allocation, the su...

we report a 73-year-old woman with primary left atrial rhabdomyosarcoma and its 1h mr spectroscopy (mrs) findings. the tumor showed a 2.8 cm sized lesion in the posteroinferior atrial wall on mri. 1h mr spectra were acquired using a point-resolved spectroscopy (press) sequence with electrocardiographic (ecg) gating and respiratory motion. the use of 1h-mrs allowed the quantification of triglyce...

B iomarkers are clinical, molecular, or image-based measurable parameters that can characterize an individual’s specific biological state, whether normal, pathological, or in response to treatment. A biomarker is considered of clinically valuable if (1) it can be measured repeatedly with accuracy and relatively rapid clinical turnaround, (2) it provides unique, superior information on patient s...

Cardiac magnetic resonance tomography is widely used method in the diagnosis of cardiovascular diseases. In last decade, new techniques have been developed to obtain quantitative parameters myocardial changes. T1 and T2 mapping are part routine CMRT protocol allow direct quantification relaxation times myocardium as well calculation extracellular volume. These important biomarkers both for vari...

BACKGROUND In hypertrophic cardiomyopathy (HCM), accumulation of myocardial collagen may play a central role in the pathogenesis of diastolic dysfunction and arrhythmia. Previous studies have suggested that peripheral levels of byproducts of collagen synthesis are reflective of myocardial extracellular matrix metabolism, although this has not been validated in detail. Given the potential clinic...