Nanoparticles possessing multiple functionalities provide synthetic handles for varied surface chemistries, making them useful for a range of applications such as biotargeting and drug delivery. However, the combination of interfering functionalities on the same particle is often challenging. We have employed a synthetic scheme involving chemical protection/deprotection to combine interfering f...

Nanogels are nano-sized three-dimensional polymer networks engineered by physical or chemical cross-linking of individual polymer chains loaded with drugs and nucleotides that swells in a good solvent

Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an oscillating magnetic field. We show that the dose of drug delivered across the membrane can be tuned by engineering the phase transition temperature of the nanogel, t...

Many biomolecules, such as proteins and genes, are presently used as therapeutics. However, their delivery to target sites inside cells is challenging because of their large molecular size, difficulties to pass cellular membranes and their susceptibility for enzymatic and chemical degradation. Nanogels, three-dimensional networks of hydrophilic polymers, are attractive carrier systems for these...

In the present study, a pH sensitive nanogel platform for gene delivery was developed. The cationic nanogels based on dendritic polyglycerol (dPG) and low molecular weight polyethylenimine units were able to encapsulate siRNA during the manufacturing process. The thiol-Michael nanoprecipitation method, which operates under mild conditions and did not require any catalyst or surfactant, was used...

Nanogel have emerged as a versatile drug delivery system for encapsulation of guest molecules. A nanoparticle which is composed hydrophilic polymer network known having range from 100-200nm. swellable and degradation properties with high loading capacity, stability, sustained targetable manner, large surface area. Therefore, nanogel are more productive than conventional micro-sized delivery. In...

In this paper, the effect of chitosan molecular weight on the characteristics (size, encapsulation efficiency, zeta potential, surface morphology and release rate) of vitamin C encapsulated tripolyphosphate cross-linked chitosan (TPP-chitosan) microspheres. The molecular weight of chitosan had a noticeable influence on the size, encapsulation efficiency, zeta potential, surface morphology and c...

By chain extension of polysarcosine with phenylalanine and cystine, nanogels are formed. The facilitate the transport dyes across an artificial mucus coated membrane their release by reductive bond cleavage.