The synthesis of a series of imidazole styrylindoles and sulfonyl styrylindoles derivatives is described. Evaluation of binding affinity and inhibitory activity against CYP24A1 identified the imidazole styrylindoles as potent inhibitors with activity greater or comparable with the standard ketoconazole. Flexible alignment and docking studies of the inhibitors in the CYP24A1 enzyme active site c...

For n ≤ 27 we present exact values for the maximum number h(n) of halving lines and eh(n) of halving pseudolines, determined by n points in the plane. For this range of values of n we also present exact values of the rectilinear cr(n) and the pseudolinear e cr(n) crossing number of the complete graph Kn. eh(n) and e cr(n) are new for n ∈ {14, 16, 18, 20, 22, 23, 24, 25, 26, 27}, h(n) is new for...

Abstract Introduction The British Society for Surgery of the Hand (BSSH) standards dictate management open hand fractures (OHFs). A wound washout and closure (WWC) in an OHF should take place within 24 hours injury if definitive treatment is not possible that timeframe. Methods retrospective cross-sectional design was used to collect data from patients with OHFs. Data taken Cerner® EPR, Powerch...

For n ≤ 27 we present exact values for the maximum number h(n) of halving lines and eh(n) of halving pseudolines, determined by n points in the plane. For this range of values of n we also present exact values of the rectilinear cr(n) and the pseudolinear e cr(n) crossing number of the complete graph Kn. eh(n) and e cr(n) are new for n ∈ {14, 16, 18, 20, 22, 23, 24, 25, 26, 27}, h(n) is new for...

Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time. Two of these were found to possess in vitro antitrypanosomal activity, namely, saringosterol (14) and 24-hydroperoxy-24-vinylcholesterol (15), with IC(50) values of 7.8 +/- 1.2 and 3.2 +/- 1.2 microM, respectively. The...

The objectives of this study were to investigate the effects of testis-epididymis cool storage on viability and progressive motility of buffalo epididymal sperm (EP) and to compare the influences of two basic semen extenders on post thaw EP viability and progressive motility. Abattoir collected buffalo testicles were allotted to three storage times (0 h: n = 10; 24 h: n = 10 and 48 h: n = 12). ...