The following chemical changes were observed during the cold storage of mussels for 6 days at 4 ◦C. Total volatile basic nitrogen (TVB-N, mg N per 100 g) and trimethylamine values (TMA-N, mg N per 100 g) were increased from 22.55 and 5.96 mg per 100 g at day 0 to 12.38 and 0.42 mg per 100 g, respectively, at the end of the storage period. The indole value and putrescine concentration were incre...

N-Heterocycle directing groups lead to selective borylation of indole at C2 or C7 controlled by heterocycle ring size. With five membered groups, is disfavoured due an increased degree distortion.

in this article, simple, convenient synthesis of 2-aryl-1-arylmethyl-1h-1,3-benzimidazole (1,2-disubstitutedbenzimidazoles) via condensation of 1,2-phenylenediamine and aromatic aldehydes using sba-pr-so3h as a nanoporous solid acid catalyst in green protocol was reported.

5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide (1; ORG27569) is a prototypical allosteric modulator for the cannabinoid type 1 receptor (CB1). Here, we reveal key structural requirements of indole-2-carboxamides for allosteric modulation of CB1: a critical chain length at the C3-position, an electron withdrawing group at the C5-position, the length of the linker betwee...

The compounds, 2-(methylsulfonyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid (DM3), 2-(phenylsulfonyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid (DM(4)), and 2-(p-toluenesulfonyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid (DM(5)) were synthesized by coupling of 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid (DM(2)) with methanesu...

served in all 26 animals treated with AAF alone, while only 7 of 27 animals treated with AAF and indole developed this lesion (13). In addition, none of the AAFand the indole treated animals developed cholangiocarcinoma, as did 4 of the AAF-treated animals. It has been shown that AAF requires biochemical activa tion in the liver, in the form of hydroxybation of the nitrogen yielding N-OH-AAF (2...

The synthesis under MW irradiation without solvent of 19 pyrazoles, of which only 8 were known, is described. They bear C-methyl groups and trityl, diphenylmethyl and benzyl groups at positions 1 and 4 of the pyrazole ring. In the reaction between pyrazole and trityl bromide an unexpected reaction occurred and 4-(9-phenyl-9H-fluoren-9-yl)-1Hpyrazole (7) was isolated.

The direct C-H annulation of anilines or related compounds with internal alkynes provides straightforward access to 2,3-disubstituted indole products. However, this transformation proceeds with poor regioselectivity in the synthesis of unsymmetrically 2,3-diaryl substituted indoles. Herein, we report the rhodium(III)-catalyzed C-H annulation of nitrones with symmetrical diaryl alkynes as an alt...

In the title compound, C27H21FN2O4, the mean planes of the indole ring systems (r.m.s. deviations = 0.0263 and 0.0160 Å) are approximately perpendic-ular to one another, making a dihedral angle of 84.0 (5)°; the fluoro-benzene ring is twisted with respect to the mean planes of the two indole ring systems at 89.5 (5) and 84.6 (3)°. In the crystal, pairs of N-H⋯O hydrogen bonds link the mol-ecule...