نتایج جستجو برای: n methyl imidazol

تعداد نتایج: 1047740  

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

An environmentally benign procedure for the synthesis of vicinal nitrohydrins via the regioselective ring opening reaction of epoxides with nitrite anion using silica-bound 3-{2-[poly(ethylene glycol)]ethyl}-substituted 1-methyl-1H-imidazol-3-ium bromide as an effective heterogeneous phase transfer catalyst was described. Short reaction time, high yield of products, simple work-up proc...

3-methyl-1-(4-sulfobuthyl)-1-H-imidazol-3ium hydrogen sulfate, as a dual acidic ionic liquid (DAIL), was found to be an efficient catalyst for the simple, rapid and green synthesis of substituted trisphenols from the condensation of different substituted phenols and 2,6-bis (methylol) phenols (BMP). DAIL catalyst efficiently promoted the reaction between phenols and BMPs with a variety of funct...

2017
Cinthia R. Millan Francisco J. Acosta-Reyes Laura Lagartera Godwin U. Ebiloma Leandro Lemgruber J. Jonathan Nué Martínez Núria Saperas Christophe Dardonville Harry P. de Koning J. Lourdes Campos

Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of drugs interacting with AT-rich DNA, such as the N-phenylbenzamide bis(2-aminoimidazoline) derivatives 1 [4-((4,5-dihydro-1H-imidazol-2-yl)amino)-N-(4-((4,5-dihydro-1H-imidazol-2...

2009
Daniel Richter John C. Kath Arnold L. Rheingold Antonio DiPasquale Alex Yanovsky

The title compound, C(12)H(13)ClN(6), was prepared by reaction of 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine with 2-(1H-imid-azol-4-yl)-N-methyl-ethanamine, and the X-ray study confirmed that chloro-substituent in six-membered ring was replaced in the reaction. The exocyclic N atom environment is approximately coplanar with the pyrrolo[2,3-d]pyrimidine [corresponding dihedral angle is 5.5 (1)°], ...

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

Journal: :Acta Crystallographica Section E Crystallographic Communications 2015

2014
Amanda K. Bolles Rina Fujiwara Erran D. Briggs Amin A. Nomeir Laura Lowe Furge Amin Nomeir

Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of CYP3A4 can lead to adverse drug-drug interactions. The substituted imidazole compounds 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl) methyl]-1-piperazinyl]pyrimidine (SCH 66712) and 1-[(2-ethyl-4-methyl1H-imidazol-5-yl)methyl]-4-[4-(trifluoromethyl)-2-pyridinyl]piperazi...

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