In order to design and manufacturing some postharvest equipment, determination of some hydrodynamic properties of crops are necessary. The quality of products in global and local markets can be increased by applying these properties and receive economical benefits. For these purpose, two local varieties of apples in the East Azerbaijan province, Iran(Asheghi and Gare Yapraq)were selected.Ashegh...

In order to design and manufacturing some postharvest equipment, determination of some hydrodynamic properties of crops are necessary. The quality of products in global and local markets can be increased by applying these properties and receive economical benefits. For these purpose, two local varieties of apples in the East Azerbaijan province, Iran(Asheghi and Gare Yapraq)were selected.Ashegh...

in order to study the effects of terminal heat stress and nitrogen on morphophysiological characteristics, anue (agronomical nitrogen use efficiency) and yield of canola, an experiment was conducted at research farm of ramin agricultural sciences and natural resources university. the experiment was arranged in split plots based on randomized complete block design with four replications. main pl...

Since the first PEGylated product was approved by the Food and Drug Administration in 1990, PEGylation has been widely used as a post-production modification methodology for improving biomedical efficacy and physicochemical properties of therapeutic proteins. Applicability and safety of this technology have been proven by use of various PEGylated pharmaceuticals for many years. It is expected t...

The covalent modification of therapeutic biomolecules has been broadly explored, leading to a number of clinically approved modified protein drugs. These modifications are typically intended to address challenges arising in biopharmaceutical practice by promoting improved stability and shelf life of therapeutic proteins in formulation, or modifying pharmacokinetics in the body. Toward these obj...

PEGylation is a well-established and effective strategy to decrease immunogenicity, which can increase the stability and in vivo half-life time. However, the generation of multi-site modified products is inevitable due to the lysine chemistry, which will bring difficulties in subsequent research, such as purification and quantification. Site-specific modification by mPEG-succinimidyl carbonate ...

TetraPEGylated canine Hb, [SP (succinimidophenyl)-PEG5K]4-canine-Hb, with PEGylation at its four reactive cysteine residues (a111 and b93) has been prepared and characterized. The hydrodynamic volume and the molecular radius of (SP-PEG5K)4-canine-Hb are intermediate to those of di- and hexaPEGylated human Hb as expected. However, the COP (colloidal osmotic pressure) of tetraPEGylated canine Hb ...