نتایج جستجو برای: na k 2cl
تعداد نتایج: 617431 فیلتر نتایج به سال:
Bumetanide is well known for its ability to inhibit the nonconductive Na+-K+-2Cl-cotransporter. We were surprised in preliminary studies to find that bumetanide in the contraluminal bath also inhibited NaCl absorption in the human sweat duct, which is apparently poor in cotransporter activity. Inhibition was accompanied by a marked decrease in the transepithelial electrical conductance. Because...
Chronic hypercalcemia (HC) is accompanied by urinary concentration defects, and functional studies indicate defects in the thick ascending limb (TAL). We hypothesize that dysregulation of renal sodium transporters may play an important role in this. Vitamin D-induced HC in rats resulted in polyuria, natriuresis, and phosphaturia. Immunoblotting revealed a marked reduction in the abundance of ra...
Mutations in the Human Na-K-2Cl Cotransporter (NKCC2) Identified in Bartter Syndrome Type I Consistently Result in Nonfunctional Transporters Abnormalities of the Na-K-Cl Cotransporter in Bartter Syndrome. Bartter syndrome, an inherited disorder of renal NaCl reabsorption, can be caused by mutations of the Na-K-Cl cotransporter (NKCC2), potassium channel (ROMK), chloride channel (ClC-Kb), or Ba...
Water-handling epithelia are sensitive to the osmotic environment. In this study, the effects of a hypo-osmotic challenge on carbachol (CCh)-induced fluid secretion was investigated using an ex vivo submandibular gland perfusion technique and intracellular pH and Ca(2+) measurements. The osmolality of the perfusion solution was altered to examine the response of the gland to a hypotonic challen...
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