Pityriasis rosea (PR) is an acute, self-limited papulosquamous dermatosis localized on the trunk and extremities, that affects otherwise healthy adolescents and young adults. Although the classic presentation is readily recognized, atypical forms may present a challenge. Many atypical forms of the disease have been reported in the literature.[1]We report two cases with atypical features. Involv...

Subungual squamous cell carcinoma is a rare phenomenon. Diagnosis of this condition is often delayed because of a resemblance to a variety of benign inflammatory conditions. Metastases are unusual, but involvement of underlying bone is common. Curative treatment is achieved by amputation of the involved digit. The index of suspicion for malignancy in the face of an inflammatory nail condition u...

Pachyonychia congenita comprises a heterogeneous group of autosomal dominantly inherited conditions manifesting with characteristic nail thickening, palmoplantar keratoderma, follicular keratosis and oral manifestations like mucosal leukokeratosis. Less frequently epidermal cysts, hair-shaft abnormalities, natal teeth and laryngeal involvement may be seen. It is distributed almost evenly throug...

OBJECTIVE To study whether obesity increases the risk of psoriatic arthritis (PsA), given that obesity is a risk factor for psoriasis and is associated with more severe disease. DESIGN Case series. We used Cox regression analysis to study the relationship between obesity and PsA while controlling for age at psoriasis onset, current body mass index (BMI), sex, family history of psoriasis, wors...

Nail biopsy is a safe and useful technique for diagnosis and management of many nail conditions. A basic understanding of nail anatomy and biology is a prerequisite for a successful nail biopsy. The patient must be adequately prepared and there needs to be excellent anesthesia and hemostasis. The type of nail biopsy depends largely on the location of the pathology in the nail unit. The techniqu...

We hypothesised that Hansen Solubility Parameters (HSPs) can be used to predict drug-nail affinities. Our aims were to: (i) determine the HSPs (δD, δP, δH) of the nail plate, the hoof membrane (a model for the nail plate), and of the drugs terbinafine HCl, amorolfine HCl, ciclopirox olamine and efinaconazole, by measuring their swelling/solubility in organic liquids, (ii) predict nail-drug inte...