Editor Alterations in the structure and appearance of the nail unit may be seen in association with a variety of dermatological disorders. 1 Because of the limited number of reaction patterns associated with the nail unit, many of the changes that are seen, such as onycholysis, pitting and subungual hyperkeratosis, are not specific. However, certain clinical findings, especially when present in...

OBJECTIVE To evaluate the therapeutic efficacy of acitretin in patients with isolated nail psoriasis. DESIGN Open study involving 36 patients with moderate to severe nail psoriasis treated with acitretin. SETTING University-based outpatient dermatology clinic specializing in nail diseases. PATIENTS A total of 27 men and 9 women (mean age, 41 years) with nail psoriasis. INTERVENTION Ther...

Onychophagia is defined as a chronic nail biting behaviour affecting about 20-30% of the general population. However, nail biting seems to be an ignored problem in a daily clinical practice. We have analysed the influence of onychophagia on quality of life (QoL) and stigmatisation level among 339 medical students with and without nail biting. Those with onychophagia demonstrated significantly h...

BACKGROUND The effect of nail polish on pulse oximetry measurements in non-hypoxic subjects has been studied extensively. Some studies found that nail polish decreased pulse-oximetry (S(pO(2))) values, whereas others found no effects from nail polish. OBJECTIVE To determine if nail polish affects S(pO(2)) measurements in mildly hypoxic subjects. METHODS At high altitude, 5 investigators, wh...

Topical therapy of onychomycosis, a fungal infection of nail plate and/or nail bed, offers an attractive alternative to treatment with systemic antifungals. To treat fungal infections locally, antifungal-loaded nail lacquers have been prepared in our laboratory. Franz diffusion cells have been used to investigate drug permeation from such lacquers into and through the nail plate in vitro. Altho...

Synopsis---The flat NAIL of some primates, including man, is unique and is usually formed from one area of the nail fold invagination called the MATRIX. This is deeply placed below two layers of EPIDERMIS and is therefore well protected from injury. Alternative .methods of nail formation more closely resemble the formation of a mammalian claw and may be regressions to a more primitive state. Co...

BACKGROUND Cutaneous T-cell lymphoma (CTCL) encompasses a broad range of lymphoproliferative diseases affecting the skin and can be clinically misleading due to its variable presentation. Nail alterations commonly appear in advanced-stage mycosis fungoides and true Sézary syndrome; however, they may be present in any stage of the disease. Although proper recognition of nail involvement in CTCL ...

BACKGROUND Although nail psoriasis affects a marked proportion of patients with psoriasis and causes significant psychological stress, only few epidemiological data characterizing patients with nail involvement are available. OBJECTIVES To gain robust data on the epidemiology and disease burden of nail psoriasis in Germany. METHODS Two nationwide, noninterventional, cross-sectional studies ...

The effective treatment of diseases of the nail remains an important unmet medical need, primarily because of poor drug delivery. To address this challenge, the diffusion, in real time, of topically applied chemicals into the human nail has been visualized and characterized using stimulated Raman scattering (SRS) microscopy. Deuterated water (D2O), propylene glycol (PG-d8), and dimethyl sulphox...

Nonunion of long bones fixed with nails may result in implant failure. Removal of a broken intramedullary nail may be a real challenge. Many methods have been described to allow for removal of the broken piece of the nail. In this paper, we are reviewing the different techniques to extract a broken nail, classifying them into different subsets, and describing a new technique that we used to rem...