PURPOSE Nonarteritic anterior ischemic optic neuropathy (NAION) is an optic nerve (ON) infarct of retinal ganglion cell (RGC) axons, and the most common cause of ON-related sudden vision loss. Estrogen has been previously proposed as a neuroprotective treatment for central nervous system ischemia. We evaluated estrogen's potential in post-ON infarct treatment to reduce neuronal loss following a...

ated with preeclampsia have been reported. However, in contrast to our case, both of these events began before delivery and involved bilateral disc edema and vision loss. Our case appears to be unique in that the symptoms appeared after delivery and the vision loss and disc edema were unilateral. The disc swelling in this case was sectoral and the visual field loss was altitudinal, characterist...

Anterior ischaemic optic neuropathy (AION) is the most frequent cause of unilateral papillary edema in patients over 45 years of age. Two main entities can be differentiated in AION: the non-arteritic form (NAION) which constitutes 96% of cases and has an estimated incidence in the USA of 2.3– 10.2 cases for every 100,000 inhabitants1; and the arteritic form (AAION), considered to be an additio...

Large spectrums of ophthalmic manifestations from the anterior to the posterior segment have been so far reported in patients with inflammatory bowel disease. Anterior ischemic optic neuropathy is caused by acute ischemic infarction of the optic nerve head and is distinguished in two different types, non-arteritic anterior ischemic optic neuroparhy (NAION) which is the most frequent type and ar...

Purpose Optic nerve (ON) damage following nonarteritic anterior ischemic optic neuropathy (NAION) and its models is associated with neurodegenerative inflammation. Minocycline is a tetracycline derivative antibiotic believed to exert a neuroprotective effect by selective alteration and activation of the neuroinflammatory response. We evaluated minocycline's post-induction ability to modify earl...

purpose: to evaluate the role of transvitreal optic neurotomy (ton) in the management of non-arteritic anterior ischemic optic neurotomy (naion). methods: sixteen eyes of 16 patients with recent onset naion (less than six weeks duration) were included in this single-masked randomized controlled trial. the patients were randomized to ton (8 eyes) versus observation alone (8 eyes). pre- and posto...

purpose : evaluation of efficacy of memantine (n-methyl-d-aspartate receptor antagonist) on visual function of patients with acute non-arteritic ischemic optic neuropathy (naion). methods : the study was conducted as interventional case series from november 2005 through november 2006 in farabi eye hospital . twenty-two patients with acute naion of less than 8 weeks duration entered the study. m...

Nonarteritic anterior ischemic optic neuropathy (NAION) has been the subject of numerous publications and editorials. Yet, meaningful progress toward understanding the pathogenesis of this entity has been limited. As the term “ischemic” would indicate, investigators have focused their efforts on defending a vascular cause. What is the evidence for ischemia in this entity that, by histopathologi...

N onarteritic anterior ischemic optic neuropathy (NAION) is the leading cause of sudden optic nerve–related vision loss in individuals over 50 years old and is caused by inadequate blood supply to the optic nerve head (1). In the United States, it affects 2.3 to 10.2 per 100,000 people over 50 years, resulting in 10,000 to 12,000 new cases per year (2,3). Little is understood concerning the pat...