BACKGROUND Availability of the opioid antagonist naloxone for lay administration has grown substantially since first proposed in 1996. Gaps remain, though, in our understanding of how people who inject drugs (PWID) engage with naloxone programmes over time. AIMS This paper aimed to address three specific evidence gaps: the extent of naloxone supply to PWID; supply-source (community or prisons...

Reward processing is linked to specific neuromodulatory systems with a dopaminergic contribution to reward learning and motivational drive being well established. Neuromodulatory influences on hedonic responses to actual receipt of reward, or punishment, referred to as experienced utility are less well characterized, although a link to the endogenous opioid system is suggested. Here, in a combi...

Background: Previous reports suggest flavonoids as potent analgesic compounds. Objectives: Based on these observations, the present study investigated anti-nociceptive action of troxerutin and neural interactions with opioidergic, serotoninergic, nitrergic systems in mice. Methods: A total 340 male mice were randomly divided into 2 categories. Each category included four experiments groups. In ...

Tramadol is used in treatment of moderate to severe pain. Nowadays tramadol overdose is one of the common emergencies. Naloxone is an antagonist which is used as a first step of treatment in these patients. This study was designed to evaluate the seizurogenic effects of naloxone in tramadol overdose. A number of 124 patients with the diagnosis of tramadol overdose were divided to receive low-do...

The endogenous opioid system has been reported to depress the cardiovascular system during shock states, since naloxone, a potent opiate antagonist, enhances recovery of hemodynamic variables in various shock states. However, the effect of naloxone on long-term survival of experimental animals exposed to hypovolemic hypotension is not clear. The present studies tested the capacity of various do...

Police officers have frequent encounters with people who use drugs, either by making an arrest for a drug-related offense or responding to drug overdose call. Yet, little is known about how police view addiction – as disease, moral failure, something else and their frameworks conceptualizing impact attitudes toward policies, including the of naloxone. This research examined officers’ adherence ...

upload poisoning is one of the most dangerous and common poisoning in iranian children. depression of the respiratory and central nervous systems may lead to significant toxicity. even low doses of uploads are dangerous in pediatrics under 6 years old. methadone is the most toxic of the uploads; small doses as low as a single tablet can lead to death. according to this information we decided to...

background:tramadol poisoning has increased in recent years. seizure is one ofthe side-effects oftramadol toxicity. there is a controversy about possible preventive effect of naloxone in tramadol poisoning induced seizure. therefore, this study was performed to compare seizure incidence in tramadol poisoning patients who received and did not receive naloxone, as an opioid antagonist. methods:th...

Opioid and non-opioid mechanisms of analgesia elicited by two kinds of footshock stress that differ only in temporal characteristics previously have been inferred on the basis of susceptibility to naloxone blockade. The present study sought further evidence on this point by comparing these two kinds of footshock analgesia for possible tolerance development and cross-tolerance with morphine. It ...

BACKGROUND Opioid-induced respiratory depression is antagonized effectively by the competitive opioid receptor antagonist naloxone. However, to fully understand the complex opioid agonist-antagonist interaction, the effects of various naloxone doses on morphine and morphine-6-glucuronide (M6G)-induced respiratory depression were studied in healthy volunteers. METHODS Twenty-four subjects rece...