Association of a polymorphism rs3775291 in the toll-like receptor 3 (TLR3) gene with age-related macular degeneration (AMD) had been investigated intensively, with variable results across studies. Here we conducted a meta-analysis to verify the effect of rs3775291 on AMD. We searched for genetic association studies published in PubMed, EMBASE and Web of Science from start dates to March 10, 201...

PURPOSE To assess the caregiver burden and factors determining the burden in patients receiving ranibizumab therapy for neovascular AMD (nAMD). METHODS This is a cross-sectional questionnaire survey of 250 matched patient caregiver dyads across three large ophthalmic treatment centres in United Kingdom. The primary outcome was the subjective caregiver burden measured using caregiver reaction ...

PURPOSE To investigate the clinical value of multifocal electroretinography (mfERG) and microperimetry and the effects of intravitreal therapy with ranibizumab (Lucentis®) on macular function in the course of neovascular age-related macular degeneration (nAMD). MATERIALS AND METHODS We conducted a prospective single-arm interventional cohort study with 20 nAMD patients older than 50 years. Ex...

Purpose To evaluate the response of intravitreal aflibercept injection (IAI) in eyes with detachment of retinal pigment epithelium (DEP) secondary to nAMD refractory to monthly ranibizumab. Patients and Methods This is a retrospective, multicenter study. All patients received 3 IAI then treated as needed every 4 weeks for 12 months. During the second year, the eyes were treated with a treat- ...

Topic This systematic review and meta-analysis provides a summary of the efficacy safety ranibizumab biosimilars relative to reference anti-vascular endothelial growth factor (VEGF) therapy for treatment neovascular age-related macular degeneration (nAMD). Methods We conducted searches from January 2003 August 2022 on Ovid MEDLINE, EMBASE Cochrane Controlled Register Trials. included studies re...

Background: Age-related Macular Degeneration (AMD) is a degenerative disease caused by multiple factors, including inflammation. This condition may lead to irreversible macular damage. Vitamin D has anti-inflammatory and immune-modulating qualities, therefore, expected protect against the development of AMD.Objective: study aimed evaluate correlation between plasma 25-hydroxyvitamin (plasma 25-...

PurposeTo develop machine learning (ML) models to predict, at baseline, treatment outcomes month 9 in patients with neovascular age-related macular degeneration (nAMD) receiving faricimab.DesignRetrospective proof-of-concept study.SubjectsPatients enrolled the phase 2 AVENUE trial (NCT02484690) of faricimab nAMD.MethodsBaseline characteristics and spectral domain optical coherence tomography (S...