The glycosylation in recombinant monoclonal antibody (rMab) drugs is a major concern in the biopharmaceutical industry as it impacts the drugs' many attributes. Characterization is important but complicated by the intricate structures, microheterogeneity, and the limitations of current tools for structural analysis. In this study, we developed a liquid chromatography-mass spectrometry (LC-MS) N...

Nanomaterials are used for numerous biomedical applications, but the selection of optimal properties for maximum delivery remains challenging. Thus, there is a significant interest in elucidating the nano-bio interactions underlying tissue accumulation. To date, researchers have relied on cell culture or animal models to study nano-bio interactions. However, cell cultures lack the complexity of...

background: removing heavy metals from industrial wastewaters by iron nanoparticles has been much noticed in the recent years. chromium is considered as one of the emphasis environmental pollutants. there are high concentrations of chromium in the wastewater of electroplating industries. magnetic iron nanoparticles are used to control and eliminate the heavy metals from industrial effluents thr...

Hot water extracts of Ginkgo biloba seeds were analyzed for the presence of ginkgotoxin (4'-O-methylpyridoxine) by reversed-phase liquid chromatography (LC) using methanol-0.05M KH2PO4 (1 + 9, v/v) adjusted to pH 3 as mobile phase. Detection was by fluorescence (excitation 280 nm, emission 370 nm). A straight line calibration curve was obtained for the 10-100 ng injected. After addition of beta...

The cycling performance and SEI composition of Si nano-particle anodes in electrolytes containing 5–25 wt% fluoroethyelene carbonate (FEC) and 3–6 wt% vinylene carbonate (VC) has been investigated by a combination of by electrochemical cycling, electrochemical impedance spectroscopy, IR-ATR and XPS. The incorporation of FEC or VC changes the cycling performance, impedance, electrode morphology,...

The scanning electron microscope (SEM) has been successfully used as an analysis tool for micro scale materials in the last few decades [1]. Recently, the large chamber (LC) SEM at Y-12 has demonstrated useful results in the analysis of large specimens at nano scales. This paper summarizes the research efforts conducted by UT and Y-12 in applying state of art 3D computer vision techniques to LC...

introduction: hydronephrosis is one of the major causes of referring infants for nuclear medicine investigation. renal dynamic study is the most reliable investigation for such children. however direct evaluation of renogram leads to generation of parameters that have no physiological interpretation. the configuration of renogram is very much dependent upon the rate at which radiopharmaceutical...

Nanostructured bupivacaine-selective molecularly imprinted 3-aminophenylboronic acid-p-phenylenediamine co-polymer (MIP) films have been prepared on gold-coated quartz (Au/quartz) resonators by electrochemical synthesis under cyclic voltammetric conditions in a liquid crystalline (LC) medium (triton X-100/water). Films prepared in water and in the absence of template were used for control studi...

Thyroid hormone has genomic and non-genomic actions in the developing and mature human. The focus of this research was to find if there was a measurable amount of thyroid hormone in the extracellular fluid of the adult rat brain and how it varied over time. To study the levels of thyroid hormone concentration in the adult brain, stereotaxic surgery was performed to implant a microdialysis cannu...