نتایج جستجو برای: nanocarrier
تعداد نتایج: 1301 فیلتر نتایج به سال:
Abstract Traditional chemotherapy remains the primary cancer treatment, but it shows low enrichment and non-specificity. Hence, we have designed a multifunctional nanocarrier based on glutathione (GSH)-responsive mesoporous silica nanoparticles (MSNs). Firstly, disulfide bonds were linked surface of silica. Then, doxorubicin (DOX) chlorin e6 (Ce6) co-loaded into pores. Finally, carboxymethyl ch...
Phytochemicals serve as a promising and effective research area with bright future. Researchers have faced serious challenge in designing developing an alternative, eco-friendly, biocompatible, cost-effective strategy greener way due to the rising incidence of cancer, expensive treatment, various limitations conventional therapy, high toxicity current anticancer drugs. Using Novel drug delivery...
Background Improving the therapeutic index of drugs is a major impetus for innovation in many therapeutic areas such as HIV, cancer, inflammatory and other infectious diseases. Polyester based dendrimers constitute a very attractive class of materials because they are less toxic, biodegradable and biocompatible. Our aim is to develop a novel ester based versatile dendritic nanocarrier that coul...
Photoreactive squaraines produce cytotoxic oxygen species under irradiation and have significant potential for photodynamic therapy. Herein we report that squaraines can be immobilized on a self-assembled nanocarrier composed of amphiphilic cyclodextrins to enhance their photochemical activity. To this end, a squaraine was equipped with two adamantane moieties that act as anchors for the cyclod...
Combination therapy of multiple drugs through a single system is exhibiting high therapeutic effects. We investigate nanocarrier mediated inhibitory effects of topotecan (TPT) and quercetin (QT) on triple negative breast cancer (TNBC) (MDA-MB-231) and multi drug resistant (MDR) type breast cancer cells (MCF-7) with respect to cellular uptake efficiency and therapeutic mechanisms as in vitro and...
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