Biomimetic Structures Annulus fibrosus (AF) repair is critical for treating disc herniation. In article 2200895, Fengxuan Han, Bin Li, and co-workers fabricate aligned core–shell nanofibrous scaffolds mimicking AF microstructure realize temporal release of drugs repair. Fast ibuprofen-ameliorated inflammation sustained TGFβ3 promote cell proliferation ECM secretion.

A promising therapy for retinal diseases is to employ biodegradable scaffolds to deliver retinal progenitor cells (RPCs) for repairing damaged or diseased retinal tissue. In the present study, cationic chitosan-graft-poly(ɛ-caprolactone)/polycaprolactone (CS-PCL/PCL) hybrid scaffolds were successfully prepared by electrospinning. Characterization of the obtained nanofibrous scaffolds indicated ...

Hybrid nanofibrous membranes of poly(lactic-co-glycolic acid) (PLGA) and chitosan with different chitosan amounts (32.3, 62.7, and 86.5%) were fabricated via a specially designed electrospinning setup consisting of two sets of separate syringe pumps and power supplies. After soaking in chloroform overnight to dissolve PLGA, the amount of chitosan in the hybrid membranes was determined. The stru...

Polymeric nanofibers that mimic the structure and function of the natural extracellular matrix (ECM) are of great interest in tissue engineering as scaffolding materials to restore, maintain or improve the function of human tissues. Electrospinning has been recently developed as an effective technique for nanofiber fabrication. In our study, the electropsinning method is used to create hybrid n...

Nanoscale three-dimensional (3D) scaffolds offer great promise for improved tissue integration and regeneration by their physical and chemical property enhancements. Electrospinning is a versatile bottom-up technique for producing porous 3D nanofibrous scaffolds that could closely mimic the structure of extracellular matrix. Much work has been committed to the development of this process throug...