In this work we synthesized Nano hydroxyapatite (HAp)  by Sol-gel method, Then we functionalized hydroxyapatite nanoparticle by use of  3-Aminopropyl trimethoxysilane (APTMS) , to improve the loading and control release of sulfasalazine drug bonded to APTMS. The drug release patterns from Sulfasalazine loaded HAp nanoparticles at pH value 8 For 6h, Sulfasalazine loaded functionalized HAp nanopa...

Purpose: Regenerative medicine offers new techniques for osteoarthritis disorders, especially while considering simultaneous chondral and subchondral regenerations. Methods: Chitosan hyaluronan were chemically bound as the phase osteogenic layer was prepared with alginate nano-hydroxyapatite (nHAP). These scaffolds fixed by fibrin glue a biphasic scaffold then examined. Results: Scanning electr...