Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein mole...

Interference-enhanced wide-field nanoparticle imaging is a highly sensitive technique that has found numerous applications in labeled and label-free subdiffraction-limited pathogen detection. It also provides unique opportunities for nanoparticle classification upon detection. More specifically, the nanoparticle defocus images result in a particle-specific response that can be of great utility ...

We investigate translocation dynamics of a vesicle cell under collision with a Janus or a homogeneous hydrophobic/hydrophilic nanoparticle. To this end, we perform dissipative particle dynamics simulation by setting the nanoparticle with different initial velocities, different chemical patterns of the surface for the nanoparticle, and different orientations (for the Janus nanoparticle). Particu...

Among a variety of hyperthermia methods, magnetic nanoparticle hyperthermia is a highly promising approach for its confined heating within the tumour. In this study we perform in vivo animal experiments on implanted prostatic tumours in mice to measure temperature distribution in the tumour during magnetic nanoparticle hyperthermia. Temperature elevations are induced by a commercially available...

By excluding metals from synthesis, growth of carbon nanostructures via unreduced oxide nanoparticle catalysts offers wide technological potential. We report new observations of the mechanisms underlying chemical vapor deposition (CVD) growth of fibrous carbon nanostructures from zirconia nanoparticles. Transmission electron microscope (TEM) observation reveals distinct differences in morpholog...

OBJECTIVES The objective of this study was to identify an injection strategy leading to repeatable nanoparticle deposition patterns in tumours and to quantify volumetric heat generation rate distribution based on micro-CT Hounsfield unit (HU) in magnetic nanoparticle hyperthermia. METHODS In vivo animal experiments were performed on graft prostatic cancer (PC3) tumours in immunodeficient mice...

P-gp plays a role in the cellular traffi cking of nanoscale drug carriers. In prior work, [ 8 ] we developed a gold nanoparticle delivery platform that preferentially targeted tumor stromal cells through surface presentation of macrolide small molecules, polarizing tumor associated macrophages towards an anti-tumor phenotype. Here, we use these novel nanoscale constructs to investigate the effe...

to resolve handling problem of nanoparticles, due to their small size, a new methodology of electro-spraying and freeze-drying was developed for colloidal nanoparticles of silica and titania to transform them to solid macro-scale nanoparticle assemblies.  the assemblies were then redispersed in an aqueous system to investigate the effect of formulation of original solutions and the process para...

This article reports an all-atom molecular dynamics simulation to study a model pulmonary surfactant film interacting with a carbonaceous nanoparticle. The pulmonary surfactant is modeled as a dipalmitoylphosphatidylcholine monolayer with a peptide consisting of the first 25 residues from surfactant protein B. The nanoparticle model with a chemical formula C188H53 was generated using a computat...

UNLABELLED Recent efforts in our laboratory have explored the use of polyacrylate nanoparticles in aqueous media as stable emulsions for potential applications in treating drug-resistant bacterial infections. These emulsions are made by emulsion polymerization of acrylated antibiotic compounds in a mixture of butyl acrylate and styrene (7:3 wt/wt) using sodium dodecyl sulfate as a surfactant. P...