DNA vaccines offer cost, flexibility, and stability advantages, but administered alone have limited immunogenicity. Previously, we identified optimal configurations of magnetic vectors comprising superparamagnetic iron oxide nanoparticles (SPIONs), polyethylenimine (PEI), and hyaluronic acid (HA) to deliver malaria DNA encoding Plasmodium yoelii (Py) merozoite surface protein MSP119 (SPIONs/PEI...

BACKGROUND Costimulation of T cells via costimulatory molecules such as B7 is important for eliciting cell-mediated antitumor immunity. Presenting costimulation molecules by immobilizing recombinant B7 on the surface of nanovectors is a novel strategy for complementary therapy. Polyhydroxyalkanoates (PHAs) are a family of biodegradable, non-toxic, biocompatible polyesters, which can be used as ...

Hair cells in the cochlea can be damaged by various insults, including noise, drugs, infections and presbycusis, which may cause sensorineural hearing loss. Gene therapy is a novel therapeutic technology that, recently, has led to the idea of treating inner ear diseases on a genetic level. Depending on their characteristics, such as a high efficiency in delivery, the capability of specific targ...

For more than a century, bacteriophage (or phage) research has enabled some of the most important discoveries in biological sciences and has equipped scientists with many of the molecular biology tools that have advanced our understanding of replication, maintenance, and expression of genetic material. Phages have also been recognized and exploited as natural antimicrobial agents and nanovector...

Podocyte damage plays a central role in the pathogenesis of idiopathic nephrotic syndrome, as well progression many chronic glomerular diseases. Targeted therapy these diseases still represents challenge. We have previously shown that c-mip (c-maf inducing protein) pivotal podocyte minimal change syndrome patients. In this context, we implement non-viral approach targeting expression podocytes ...

A images of tumor cells being vaporized in beams of colorful light, a video produced by the National Cancer Institute proclaims, “the science is at our fingertips.” The science being referred to, which is 80,000 times smaller than the breadth of a single ridge of skin on a human fingertip, is cancer nanotechnology. Nanotechnology, the study of science on a level the width of ten hydrogen atoms,...

Block-polymer nanoparticles are now well-known candidates for the delivery of various non-soluble drugs to cells. The release of drugs from these nanoparticles is a major concern related to their efficiency as nanovectors and is still not completely deciphered. Various processes have been identified, depending of both the nature of the block-polymer and those of the drugs used. We focused our i...