Prostaglandins (PGs) are biologically active lipids derived from the cyclooxygenase (COX)-mediated metabolism of arachidonic acid. They are constitutively produced in certain tissues (eg, brain, gut, and kidney), and their synthesis is increased at sites of inflammation. Prostanoids function as important mediators of inflammation and modulate a variety of physiological processes, including main...

Finding any new job takes time and resources. Finding the right job is especially difficult. For workers and employers alike, it is costly to determine whether they will strike a good match regarding pay, location, schedule, skills, work environment, and so on. These costs hamper not only individual workers and businesses but also the wider economy. The greater the amount of search friction, th...

Following the binding of B cell receptors (BCR) to cognate antigens exposed on presenting cells, B cells rapidly spread over antigen-containing surface. During B cell spreading, antigen-BCR microclusters are continually assembled at the periphery of the contact area between the cells. The initial spreading response is followed by a contraction phase, which results in the accumulation of antigen...

There has been great focus in the recent trade theory literature on the introduction of firm heterogeneity into trade models. This introduction has highlighted the importance of the entry/exit decision of firms in response to changes in trade barriers. However, it is typical in many of these models to use iceberg transport costs as a general form of trade barriers that can be interchangeable wi...

700 www.thelancet.com Vol 373 February 28, 2009 6 Hohnloser SH, Connolly SJ, Crijns HJGM, Page RL, Seiz W, Torp-Petersen C. Rationale and design of ATHENA: a placebo-controlled, double-blind, parallel arm trial to assess the effi cacy of dronedarone 400 mg bid for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fi brillation/atrial fl utter. J Ca...

In this issue of Blood, Boudreau et al report that activated platelets release respiratory-competent mitochondria either as free organelles or packed in platelet microparticles. Secreted phospholipase A2 IIA hydrolyzes the membrane of these free mitochondria to generate proinflammatory mediators. Results from this study are important in 3 key aspects. First, the authors show that activated plat...

eve the adam's wife is the first woman that is mentioned in myths and narratives. the verses of the quran do not explain quality of eve's creation. meanwhile some of traditions exist in early hadith sources that consider eve or generally women as being created from man or from certain limb (rib) of him. in this article, these hadith sources having been classified and quoted, are studi...