An understanding of the physical mechanisms underlying the atomization process from a spray device can reveal important information leading to more effective device design. A commercial nasal spray device exhibiting low pressure atomization was tested to obtain spray formation, its characteristics, droplet size distribution, and droplet velocity. High speed laser photography combined with an in...

The potential for a pharmacokinetic interaction between butorphanol nasal spray and cimetidine, under steady state conditions, was evaluated in 16 healthy male volunteers. Subjects received either a 1 mg butorphanol nasal spray every 6 h or a 300 mg cimetidine tablet every 6 h on days 1 4, the combination of two compounds every 6 h on days 5-8 and the original treatment as described in the firs...

This study aims to investigate the significance of Upper And Lower Airway-Combined Therapy (ULACT) by comparing the treatment protocols for pure Allergic Rhinitis (AR) and AR associated with lower airway inflammation. A total of 103 cases of AR that were diagnosed in a clinic service were divided according to their association with lower airway inflammation into three different groups: group A ...

OBJECTIVES/HYPOTHESIS We aimed to evaluate the effectiveness of low-concentration hypochlorous acid (HOCl) nasal irrigation compared to isotonic normal saline for pediatric chronic rhinosinusitis. STUDY DESIGN This was a randomized, prospective, active-controlled study. METHODS This study investigated the effectiveness of 4 weeks of low-concentration hypochlorous irrigation by analyzing fiv...

Background: Treatment of adenoid hypertrophy is generally planned in accordance with the degree of airway obstruction and related morbidity. If surgical treatment is indicated, the individual risk/ benefit analysis of patients should be assessed in terms of anesthetic and postoperative complications. Although there are few alternative treatment options, intranasal steroid applications may be co...