In the effort to advance toward a theory of cellular function that is not completely mechanistic, I have encountered a variable whose significance is often overlooked. This is the degree of heterogeneity of organic tissue, which may vary from highly homogeneous conditions to quite large degrees of heterogeneity, primarily with respect to chemical bonding. For several decades, I have dealt with ...

Cell Alterations, edited by Fleckerstein A, Rona G. Baltimore, University Park Press, 1975, p 487 28. Buja LM, Ferrans VJ, Mayer RJ, Roberts WC, Henderson ES: Cardiac ultrastructural changes induced by daunorubicin therapy. Cancer 32: 771, 1973 29. Ainger LE, Bushore J, Johnson WW, Ito J: Daunomycin: A cardiotoxic agent. J NatI Med Assoc 63: 261, 1971 30. Ferrans VJ, McAllister HA Jr, Haese WH:...

INTRODUCTION Traditio nally in E urope, the state has had ultimate authority. With the creation of the E uropean Union, however, states have delegated some authority and binding decisio n-n. 1aking power to supranational institutio ns. This shift in the power structure has not only led to the consolidati o n of control away from the state toward supranati onal institutio ns, but has also led to...

A complementary DNA (cDNA) clone (B4) encoding the catalytic subunit of a cAMP-dependent protein kinase (PKAc) was isolated from a XgtlO rat brain cDNA library, using a synthetic oligonucleotide probe whose sequence was based on the known amino acid sequence of a bovine cardiac PKAc. Sequence analysis of this clone revealed a region of 1002 nucleotides which encodes a protein that is 92% homolo...

Danson, M. J. & Perham, R. N. (1976) Biochem. J. 159, 677-682 Danson, M. J., Hooper, E. A. & Perham, R. N. (1978a) Biochem. J. 175, 193-198 Danson, M. J., Fersht, A. R. & Perham, R. N. (1978b) Proc. Natl. Acad. Sci. U.S.A. in the press Durchschlag, H. (1975) Biophys. Struct. Mech. 1 169-188 Eley, M. H., Namihara, G., Hamilton, L., Munk, P. & Reed, L. J. (1972) Arch. Biochem. Biophys. 152, 655-6...

Cell Alterations, edited by Fleckerstein A, Rona G. Baltimore, University Park Press, 1975, p 487 28. Buja LM, Ferrans VJ, Mayer RJ, Roberts WC, Henderson ES: Cardiac ultrastructural changes induced by daunorubicin therapy. Cancer 32: 771, 1973 29. Ainger LE, Bushore J, Johnson WW, Ito J: Daunomycin: A cardiotoxic agent. J NatI Med Assoc 63: 261, 1971 30. Ferrans VJ, McAllister HA Jr, Haese WH:...

Treatment of simian virus 40-transformed 3T3 cells with 1 ¡IMß-all-frans-retinoic acid (RA) resulted in a 5to 6-fold enhancement of plasminogen activator (PA) release. Intracellular PA levels rose to twice control levels. Confluent 3T3 cells were less responsive to RA. In 6 of 10 experiments, no increase in 3T3 cell PA levels was noted, although up to a 2.5-fold enhancement of PA elaboration ...

E-cadherin is a ( 'a*-dependent cell adhesion molecule which plays an important role in normal growth and development via mediation of homotypic, homophilic cell-cell interaction. Recent studies suggest that E-cadherin may be important in neoplastic progression as well, partic ularly as a suppressor of invasion. We have previously demonstrated that the invasive phenotype of rat prostate cancer ...

Story in Brief Corn steep liquor (CSL) and fermented ammoniated condensed whey (FACW) were compared to cottonseed meal (CS1\I) as protein sources f())' wintering 6 I lactating first-calf Hereford heifers and 32 yearling HerefOl'd heifers on nati\'e range. Cattle were allotted by weight and individually fed 6 days per week fill' 12 weeks one of four protein treatments: negative control (I\C). po...

We consider graph coloring and related problems in the distributed message-passing model. Locallyiterative algorithms are especially important in this setting. These are algorithms in which each vertex decides about its next color only as a function of the current colors in its 1-hop neighborhood. In STOC’93 Szegedy and Vishwanathan showed that any locally-iterative (∆ + 1)-coloring algorithm r...