INTRODUCTION This protocol aims to describe the objective and methods to be followed in a systematic review of qualitative studies on barriers and facilitators to physical activity (PA) in people with hip or knee osteoarthritis (OA). METHODS AND ANALYSIS MEDLINE, EMBASE, PhychINFO, Web of Science, CINAHL, SPORTDiscus, Scopus and grey literature sources will be electronically searched. Hand se...

The Department of Health has asked the National Institute for Health and Care Excellence (NICE) to produce guidance on using total hip replacement and resurfacing arthroplasty in the NHS in England and Wales. The Appraisal Committee has considered the evidence submitted and the views of non-manufacturer consultees and commentators, and clinical specialists and patient experts. This document has...

Objective To assess the association between different types of organisation and the results from economic evaluations. Design Retrospective pairwise comparison of evidence submitted to the technology appraisal programme of the National Institute for Clinical Excellence (NICE) by manufacturers of the relevant healthcare technologies and by contracted university based assessment groups. Data sour...

The Department of Health asked the National Institute for Health and Clinical Excellence (NICE) to produce guidance on using denosumab for the prevention of skeletal-related events in adults with bone metastases from solid tumours in the NHS in England and Wales. The Appraisal Committee has considered the evidence submitted and the views of non-manufacturer consultees and commentators, and clin...

This study investigated the e€ect of a process versus a results focus as well as a group versus individual-based approach to performance appraisals. Four experimental conditions were investigated, with dependent variables of appraisal satisfaction, perceived accuracy of the performance appraisal, expectations of performance improvement, and actual performance. The results showed that a process ...

One of the key roles of the English National Institute for Health and Clinical Excellence (NICE) is technology appraisal. This essentially involves evaluating the cost effectiveness of pharmaceutical products and other technologies for use within the National Health Service. Based on a content analysis of key documents which shed light on the nature of appraisals, this paper draws attention to ...

OBJECTIVES High-quality evidence-based clinical practice guidelines can guide diagnosis and treatment to optimise outcomes. The purpose of this study was to evaluate the quality and content of national and international guidelines on hypertensive disorders of pregnancy. DATA SOURCES The MEDLINE database, the National Guideline Clearinghouse and several international databases were searched fo...

The National Institute for Health and Clinical Excellence (NICE) provides guidance to the National Health Service (NHS) in England and Wales on funding and use of new technologies. This study examined the impact of evidence, process and context factors on NICE decisions in 2004-2009. A data set of NICE decisions pertaining to pharmaceutical technologies was created, including 32 variables extra...

david lawrence sackett, oc, md, frsc, frcp was an american-canadian physician, trialist, and teacher. he is best known as one of the pioneers of evidence-based medicine (ebm), which is arguably the most important movement in medicine over the past three decades. he founded the first clinical epidemiology department in mcmaster university in hamilton, canada in 1967. in addition, he was the head...

A comprehensive and behaviorally formulated theory for psychopathology disorders termed as behavioral-cognitive inhibition theory is presented. It constitutes an integration and re-formulation of several influential psychological theories of psychopathology and empirical findings in imagery research. According to the behavioral-cognitive inhibition theory the development of PTSD and other psych...