Multiple endocrine neoplasia type 2 is an autosomal-dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the rearranged during transfection proto-oncogene, which encodes the receptor tyrosine kinase, on chromosome 10. It has a strong penetrance of medullary thyroid carcinomas and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism. M...

UNLABELLED objectives: To evaluate the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its clinical significance in cervical cancer and cervical intraepithelial neoplasia. METHODS PBK/TOPK expression was detected in 28 cases of low-grade cervical intraepithelial neoplasia (CINI), 62 cases of high-grade intraepithelial neoplasia and 80 cases of cervical can...

Multiple endocrine neoplasia (MEN) types 1 and 2 are genetic diseases that are inherited as autosomal traits. The major clinical manifestations of multiple endocrine neoplasia type 1 include the so-called "3 P's": parathyroid, pituitary, and pancreatic tumors, including gastroenteroneuroendocrine tumors. Genetic testing can be performed on patients and the potential carriers of the menin gene m...

Punch biopsy specimens of the cervix were examined both histologically and for the presence of human papillomavirus (HPV) DNA sequences. The presence of HPV DNA sequences was sought with the Southern blot technique using radioactively labelled HPV-6, 11, 16, and 18 DNA probes, both together and separately. Twenty six biopsy specimens were examined. Histological examination showed cervical intra...

conclusions the high prevalence of hpv in abnormal cytology underlines to the fact that the presence of hpv is a critical factor in the development of cervical cancer. the use of hpv dna techniques could actually become an effective and fast means of ascertaining the presence of hpv in abnormal cytology. results result showed a 100% presence of high risk hpv in all the samples with abnormal cyt...

A rare case of anal intraepithelial neoplasia arising in an inflammatory cloacogenic polyp is reported. While the occurrence of neoplasia complicating benign anal conditions is recognised, this case re-emphasises the need for careful histological examination of all perianal lesions.

ABSTRACT: Hypothyroidism is rarely observed in cats. This article reports the case of a thirteen-year-old feline with one-year history bilateral cervical swelling that had majorly grown size two weeks prior to animal’s admission. The cat presented dysphonia, lethargy, weight gain, and constipation. On physical examination, hypothermia was observed, rectal temperature 36.5 ºC. Fine-needle aspira...

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of ‘cancer stem cells (CSCs)’ in PDAC and molecular markers for them, cell dynamics vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk1), known as CSC marker PDAC. Using genetic lineage tracing with dual-recombinase system live imaging, sh...

OBJECTIVE There is no consensus on whether, when and how to surveil an ileal pouch. The aims of this study were to evaluate experts' opinions and practice patterns on pouch surveillance and to determine if they were associated with detection of neoplasia. METHODS Eligible physicians were identified by searching the literature in MEDLINE and the physician list of the Crohn's and Colitis Founda...