Uramustine (or uracil mustard, 5-aminouracil mustard, chlorethaminacil), is an bi-functional alkylating nitrogen mustard agent that utilizes a natural product to carry the nitrogen mustard group to a selective metabolite site. The potential for applying uramustine as a therapeutic drug appeared in the 60’s, where its potential as a treatment tool for metastatic Wilms’s tumor was notes (Wilm’s t...

Wilms’ tumor (WT)/ Nephroblastoma is the second common abdominal malignancy and most common malignant renal tumor in children [1]. Twelve % of WT patients have metastases at initial presentation [2]. Common hematogenous metastatic site of WT include the lung, liver, and contralateral kidney. Less common sites include the bone, skin, brain, and orbit [2]. The lung is most common hematogenous met...

Mitchell, J. D., Baxter, Thelma J., Blair-West, J. R., and McCredie, D. A. (1970). Archives of Disease in Childhood, 45, 376. Renin levels in nephroblastoma (Wilms' tumour). Report of a renin secreting tumour. The case history is reported of a child aged 1 year 10 months with malignant hypertension in association with Wilms' tumour. In addition there was a marked electrolyte disturbance, with h...

Today the prognosis in children with nephroblastoma is excellent. With the combination of surgery, chemotherapy and radiation more than 80% of children can be cured. Because of acute toxicity and late effects of treatment (scoliosis, cardiotoxicity, fertility problems and second malignancies) a major issue in the management of children with this kind of malignancy is the reduction of chemothera...

BACKGROUND Adult Wilms tumor (WT, nephroblastoma) is a rare, but well-described renal neoplasm. Although inferior vena cava tumor thrombosis is present in up to 10% of Wilms tumors in childhood, only few cases of this clinical manifestation in adults have been reported. To the best of our knowledge, this is the first case of adult WT infiltrating into inferior vena cava (IVC) with concomitant d...