In this study, a computational model was developed using commercial finite element analysis package COMSOL Multiphysics (Burlington, MA) to simulate the electrical double layer (EDL) structure and quantify the EDL capacitance for the first time. In the modeling the electrochemical process at an EDL structure was considered by solving the Poisson, Nernst-Plank and Butler-Volmer equations without...

The membrane potential of frog sartorius muscle fibers in a Cl- and Na-free Ringer's solution when sucrose replaces NaCl is about the same as that in normal Ringer's solution. The K(+) efflux is also about the same in the two solutions but muscles lose K and PO(4) in sucrose Ringer's solutions. The membrane potential in sucrose Ringer's solution is equal to that given by the Nernst equation for...

Corpus striatum neurons acutely dissociated from the brains of young adult rats had membrane surfaces suitable for G omega-seal recording. Whole-cell current-clamp and voltage-clamp recordings indicated that the cells remained electrically excitable after dissociation. Cell-attached recordings frequently revealed single-channel openings in the presence of dopamine or of the D2 dopamine agonist ...

In this work, we are interested in effects of a simple profile of permanent charges on ionic flows. We determine when a permanent charge produces current reversal. We adopt the classical Poisson-NernstPlanck models of ionic flows for this study. The starting point of our analysis is the recently developed geometric singular perturbation approach for Poisson-Nernst-Planck models. Under the setti...

In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic-abiotic bioprotonic de...

The Poisson-Boltzmann (PB) equation is conventionally used to model the equilibrium of bulk ionic species in different media and solvents. In this paper we study a new PoissonBoltzmann type (PB n) equation with a small dielectric parameter 2 and nonlocal nonlinearity which takes into consideration of the preservation of the total amount of each individual ion. This equation can be derived from ...

Oxygen reduction on the surface of a rotating disk electrode RDE in 0.5 M H2SO4 is simulated by including mass transfer, adsorption, and charge transfer. A generalized model for the adsorption and reaction of several species is introduced. The oxygen reduction reaction is simulated as a limiting case where oxygen is the only species adsorbed, and oxygen reduction is the only reaction that takes...

Monitoring the plasma membrane potential and its changes can be a time consuming and challenging task especially when conventional electrophysiological techniques are used. The use of potentiometric fluorophores, namely tetramethylrhodamine methylester (TMRM), and digital imaging devices (laser scanning confocal microscopy) provides reliable and time efficient method. Two scorpion pore-forming ...

Recently measured water permeability through bilayers of different lipids is most strongly correlated with the area per lipid A rather than with other structural quantities such as the thickness. This paper presents a simple three-layer theory that incorporates the area dependence in a physically realistic way and also includes the thickness as a secondary modulating parameter. The theory also ...

We investigate a system of N Brownian particles with the Coulomb interaction in any dimension d ≥ 2, and we assume that the initial data are independent and identically distributed with a common density ρ0 satisfying ∫ Rd ρ0 ln ρ0 dx < ∞ and ρ0 ∈ L 2d d+2 (Rd ) ∩ L1(Rd, (1+ |x|2) dx). We prove that there exists a unique global strong solution for this interacting partsicle system and there is n...