Hub location problems are strategic network planning problems. They formalise the challenge of mutually exchanging shipments between a large set of depots. The aim is to choose a set of hubs (out of a given set of possible hubs) and connect every depot to a hub so that the total transport costs for exchanging shipments between the depots are minimised. In classical hub location problems, the un...

The Tree-of-Hubs Location Problem is studied. This problem, which combines several aspects of some location, network design and routing problems, is inspired by those transportation systems in which (i) several locations send and receive a product, and (ii) the performance can be improved by using transshipment points (hubs) where the product is collected and distributed. We want to locate a fi...

The large-scale functional MRI connectome of the human brain is composed of multiple resting-state networks (RSNs). However, the network dynamics, such as integration and segregation between and within RSNs is largely unknown. To address this question we created high-resolution "frequency graphlets", connectivity matrices derived across the low-frequency spectrum of the BOLD fMRI resting-state ...

Lateralized brain regions subserve functions such as language and visuospatial processing. It has been conjectured that individuals may be left-brain dominant or right-brain dominant based on personality and cognitive style, but neuroimaging data has not provided clear evidence whether such phenotypic differences in the strength of left-dominant or right-dominant networks exist. We evaluated wh...

BACKGROUND Extreme shyness in childhood arising from behavioral inhibition (BI) is among the strongest risk factors for developing social anxiety. Although no imaging studies of intrinsic brain networks in children with BI have been reported, adults with a history of BI exhibit altered functioning of frontolimbic circuits and enhanced processing of salient, personally relevant information. BI i...

In 2004 the Power Systems and High Voltage Laboratories at ETH initiated the research project ”Vision of Future Energy Networks” (VoFEN), which applies a greenfield approach to the design of future energy systems. The main aspect of the project is the consideration of multiple energy carriers, i.e. the analysis is not restricted to electricity but also considers other energy carriers such as na...

Hubs are special facilities that serve as switching, transshipment and sorting points in many-to-many distribution systems. The hub location problem is concerned with locating hub facilities and allocating demand nodes to hubs in order to route the traffic between origin–destination pairs. In this paper we classify and survey network hub location models. We also include some recent trends on hu...

Combining diffusion magnetic resonance imaging and network analysis in the adult human brain has identified a set of highly connected cortical hubs that form a "rich club"--a high-cost, high-capacity backbone thought to enable efficient network communication. Rich-club architecture appears to be a persistent feature of the mature mammalian brain, but it is not known when this structure emerges ...

A question to be addressed in the present study is how different the eyes-closed (EC) and eyes-open (EO) resting states are across frequency bands in terms of efficiency and centrality of the brain functional network. We investigated both the global and nodal efficiency and betweenness centrality in the EC and EO resting states from 39 volunteers. Mutual information was used to obtain the funct...

Design of network, through which data, packages or even people can be transported, is an important issue for achieving a desired level of service quality at an acceptable cost. For this purpose, it is possible to design a network comprised of nodes that are connected to each other with dedicated lines. However, this kind of solution will not be cost effective. In order to decrease the total tra...