نتایج جستجو برای: neural differentiation

تعداد نتایج: 515348  

2007
Wei Lu Jiao Wang Tieqiao Wen

G13 signaling pathway is closely related with differentiation of neural stem cells. RhoGDIγ is a key factor in this pathway. When Rho-GDIγ is silenced by using RNAi, the neural stem cell appears distinguished morphological change. The results indicate that the silenced cells showed the tendency of stimulative differentiation of neural stem cells.

2017
Ulrike Fischer Ella Kim Andreas Keller Eckart Meese

There is growing evidence that gene amplifications are an attribute of normal cells during development and differentiation. During neural progenitor cell differentiation half of the genome is involved in amplification process. To answer the question how specific amplifications occur at different stages and in different lineages of differentiation we analyzed the genes CDK4, MDM2, EGFR, GINS2, G...

Journal: :Proceedings of the ... AAAI Conference on Artificial Intelligence 2022

Multilingual neural machine translation (MNMT) aims to translate multiple languages with a single model and has been proved successful thanks effective knowledge transfer among different shared parameters. However, it is still an open question which parameters should be ones need task-specific. Currently, the common practice heuristically design or search language-specific modules, difficult fi...

2013
Zhe-Hao Zhang Ying-Ying Lu Jianbo Yue

Nicotinic acid adenine dinucleotide phosphate (NAADP) is an endogenous Ca(2+) mobilizing nucleotide presented in various species. NAADP mobilizes Ca(2+) from acidic organelles through two pore channel 2 (TPC2) in many cell types and it has been previously shown that NAADP can potently induce neuronal differentiation in PC12 cells. Here we examined the role of TPC2 signaling in the neural differ...

Journal: :The Journal of biological chemistry 2012
Claudiana Lameu Cleber A Trujillo Telma T Schwindt Priscilla D Negraes Micheli M Pillat Katia L P Morais Ivo Lebrun Henning Ulrich

The diffusible messenger NO plays multiple roles in neuroprotection, neurodegeneration, and brain plasticity. Argininosuccinate synthase (AS) is a ubiquitous enzyme in mammals and the key enzyme of the NO-citrulline cycle, because it provides the substrate L-arginine for subsequent NO synthesis by inducible, endothelial, and neuronal NO synthase (NOS). Here, we provide evidence for the particip...

2016
Yang Zhao Qingxi Liu He Sun Deyong Chen Zhaohui Li Beiyuan Fan Julian George Chengcheng Xue Zhanfeng Cui Junbo Wang Jian Chen

Electrical property characterization of stem cells could be utilized as a potential label-free biophysical approach to evaluate the differentiation process. However, there has been a lack of technology or tools that can quantify the intrinsic cellular electrical markers (e.g., specific membrane capacitance (Cspecific membrane) and cytoplasm conductivity (σcytoplasm)) for a large amount of stem ...

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