neural tube defects (ntds) are complex problem of central nervous system including brain and spinal cord. anencephaly and myelomeningocele are the two most common forms of ntds. epidemiological studies reveal that genetic and environmental factors are responsible for the development of ntds. during embryogenesis large numbers of extrinsic and intrinsic factors are responsible for the closer of ...

We conducted a study of published work to evaluate the evidence for the hypothesis that environmental exposure and parental occupation are risk factors for neural tube defects. As other risk factors such as maternal illnesses, medication, and dietary factors have been reviewed before, this review only summarizes this information. In studies concerning environmental pollution, only a few weak as...

Neural tube defects are a group of developmental abnormalities that results from failure of fusion of the caudal neural tube, representing one of the most common group of malformations of human structure. The etiology is thought to be multifactorial in the vast majority of the cases, but other possible causes are heterogeneous and include chromosome abnormalities, single gene disorders and tera...

Radioactive fallout; Chernobyl; Fukushima; Neural tube defects; Anencephaly; Spina bifida Abstract Possible link between radioactivity and the occurrence of neural tube defects is a long lasting debate since the Chernobyl nuclear fallout in 1986. A recent report on the incidence of neural defects in the west coast of USA, following Fukushima disaster, brought another evidence for effect of radi...

STUDY OBJECTIVE The aim was to assess the association of neural tube defects with periconceptional vitamin supplementation. DESIGN This was a matched, population based case-control study. SETTING Western Australia, 1982-1984. PARTICIPANTS Mothers of 77 cases (93% of those eligible) with isolated neural tube defects, mothers of 77 matched control infants with defects other than neural tube...

A total of 227 mothers enrolled for periconceptional multivitamin supplementation because of previous neural tube defect (NTD) births took vitamins for less than the recommended minimum period (at least 28 days before conception until two menstrual periods have been missed). Of 213 examined infants/fetuses born to these partially supplemented mothers, two had NTD, one of whom followed four prev...

Prenatal diagnosis with application of the Amniotic fluid (Amniocentesis: AC) and chorionic villi sampling {CVS) is a general aspect of application in Human Genetics which facilitate the diagnosis of different Genetic defects, enclosing chromosomal abnormalities and Genosomopathies. Diagnosis of Genetic defects for AC and CVS is between 16-20th and 8-12th weeks of gestation respectively. Allica...

1 MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the MRC vitamin study. Lancet 1991;338:132–7. 2 Little J, Elwood M. Geographic variation. In: Elwood JM, Little J, Elwood JH, eds. The epidemiology and control of neural tube defects. Oxford: Oxford University Press, 1992:96–145. 3 Rogers SC, Weatherall JAC. Anencephalus, spina bifida and congenital hydrocephalus....