ÐEstrogens can in ̄uence the survival, plasticity and function of many adult neurons. Many of these effects, such as neurite outgrowth and increased dendritic spine density, are mediated by changes in neuronal cytoskeletal architecture. Since neuro®lament proteins play a key role in the maintenance and remodeling of the neuronal cytoskeleton, we postulated that changes in neuro®lament light chai...
