نتایج جستجو برای: neuroaxonal dystrophy
تعداد نتایج: 22776 فیلتر نتایج به سال:
The rapid activation and feedback regulation of many G protein signaling cascades raises the possibility that the critical signaling proteins may be tightly coupled. Previous studies show that the PDZ domain containing protein INAD, which functions in Drosophila vision, coordinates a signaling complex by binding directly to the light-sensitive ion channel, TRP, and to phospholipase C (PLC). The...
In Drosophila photoreceptors the multivalent PDZ protein INAD organizes the phototransduction cascade into a macromolecular signaling complex containing the effector PLC, the light-activated TRP channels, and a regulatory PKC. Previously, we showed that the subcellular localization of INAD signaling complexes is critical for signaling. Now we have examined how INAD complexes are anchored and as...
InaDp215 is a point mutation that affects photoreceptor function in Drosophila. To understand the molecular basis of the defect, we isolated the InaD gene and found it encodes a photoreceptor-specific polypeptide of 674 residues. Within its sequence are two repeats that share remarkable homology with a family of cytoskeleton-associated proteins that are involved in signal transduction. Patch-cl...
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder which is considered to be the most common cause of dementia. It has a greater impact not only on the learning and memory disturbances but also on social and economy. Currently, there are mainly single-target drugs for AD treatment but the complexity and multiple etiologies of AD make them difficult to obtain d...
This extended-abstract introduces CO-PLAN, a two-phase propositional planning system for the cost-optimal case. During the first phase, CO-PLAN constructs the n-step plangraph for increasing values of n, passing the corresponding decision problem at each stage to a modified Boolean satisfiability procedure. This procedure determines whether an nstep plan exists, and if so identifies a plan that...
*Unidad Gestión Clínica de Salud Mental. Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga. Málaga, Spain; **Instituto de Investigación I+12, Hospital 12 de Octubre, Psychiatry Service, Madrid 28041, Spain; Department of Psychiatry, Complutense University of Madrid, 28040, Spain; ***Neurosciences Program, Institut Hospital del Mar d’Investigacions...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید