5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a genetic disorder that can occur at any age and can be easily detected by increased homocysteinemia. In adolescence/adult onset forms, the clinical picture is often complex with association of various neurological features and thrombosis.Here we report the cases of two adult siblings who experienced focal epilepsy at 18 years old ...

BACKGROUND Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme for producing γ-aminobutyric acid, and it has been suggested that antibodies against GAD play a role in neurological conditions and type 1 diabetes. However, it is not known whether dementia appears as the sole neurological manifestation associated with anti-GAD antibodies in the central nervous system. CASE PRESENTATION...

We present two patients known to have prostate cancer who presented with acute cerebellar signs. The neurological deficit of the first patient was due to a paraneoplastic cerebellar manifestation and progressed, despite evidence of response of the primary prostate tumour to hormonal manipulation. The second case, resulting from a solitary cerebellar metastasis, was amenable to surgical interven...

Intramedullary spinal cord metastasis is an uncommon manifestation of systemic tumor. We present a case of metastatic mass inside the thoracic spinal cord 6 years after nephrectomy because of renal cell carcinoma. The parenchymal lesion was resected totally and the histologic examination confirmed it as renal cell carcinoma metastasis. The patient's neurological function improved apparently unt...

Huntington's disease (HD) is a rare, autosomal dominant, progressive neurodegenerative disorder. HD manifests with triad of motor, cognitive, and psychiatric symptoms. Our patient, 39-years-old married female over nine-year history psychotic The patient was diagnosed treated for schizophrenia. Over the last 2-3 years, had decline in her Activities Daily Living, instrumental activities daily liv...

Coronavirus disease 2019 (COVID-19) is one of the worst pandemics in history, caused by severe acute respiratory syndrome coronavirus-2, a novel zoonotic coronavirus. COVID-19 can present from asymptomatic or mild infection to rapidly progressive, distress syndrome, and death. Neurological presentation not so uncommon now. Super refractory status epilepticus (SRSE) be possible manifestation dis...

mitochondrial disorders (mids) may occasionaly go along with dysmorphism but hand deformities, as in the following case, have been only rarely reported. a 72 year old female with ptosis, hypoacusis, tremor, myopathy, diabetes mellitus, arterial hypertension, severe cardiac disease, pulmonary hypertension, gastric carcinoid, hepatopathy, generalised atherosclerosis, anemia, polyarthrosis, and hy...

New corona virus named as COVID-19 can presented not only by respiratory symptoms, but also with other organs involvement such gastrointestinal, cardiac, renal and neurological symptoms. We reported a patient who peripheral facial nerve palsy evaluations revealed infection. suggest from this case, that infection may be potential cause of paralysis during terrible pandemic, neurologists will nee...