OVER the last years, a growing body of information has accumulated in the anesthesia literature about the advantages and pitfalls of various techniques used for quantitatively monitoring neuromuscular function in routine anesthetic practice and the associated incidence (and consequences) of residual neuromuscular block in the postoperative period. Many methods are available, ranging from quanti...

OVER the last years, a growing body of information has accumulated in the anesthesia literature about the advantages and pitfalls of various techniques used for quantitatively monitoring neuromuscular function in routine anesthetic practice and the associated incidence (and consequences) of residual neuromuscular block in the postoperative period. Many methods are available, ranging from quanti...

Intensivists use neuromuscular blocking agents for a variety of clinical conditions, including for emergency intubation, acute respiratory distress syndrome, status asthmaticus, elevated intracranial pressure, elevated intra-abdominal pressure, and therapeutic hypothermia after ventricular fibrillation-associated cardiac arrest. The continued creation and use of evidence-based guidelines and pr...

OBJECTIVE The relationship between neuromuscular blocking agents and neuromuscular dysfunction acquired in critical illness remains unclear. We examined the association between neuromuscular blocking agents and ICU-acquired weakness, critical illness polyneuropathy, and critical illness myopathy. DATA SOURCES PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, Cumu...

OVER the last years, a growing body of information has accumulated in the anesthesia literature about the advantages and pitfalls of various techniques used for quantitatively monitoring neuromuscular function in routine anesthetic practice and the associated incidence (and consequences) of residual neuromuscular block in the postoperative period. Many methods are available, ranging from quanti...

PURPOSE Myasthenia gravis (MG) is an autoimmune disease interfering with neuromuscular transmission. Patients are at risk of postoperative residual curarization (PORC) if nondepolarizing muscle relaxants are used. Clinically inapparent insufficient muscle strength may result in hypoventilation and postoperative bronchopneumonia. We describe a cohort of 117 cases in which sugammadex was used in ...

STUDY OBJECTIVE To evaluate and compare the efficacy of various pretreatment agents to attenuate or prevent opioid-induced muscle rigidity using a well-established, previously described clinical protocol. DESIGN Prospective, controlled, single-blind, partially randomized study. SETTING Large medical center. PATIENTS ASA physical status I-III patients undergoing elective surgical procedure...

AN initial transient increase in the size of the muscle twitch before the onset of paralysis has been described as characteristic following the intravenous injection of a depolarizing neuromuscular blocking agent. During several series of experiments undertaken in the study of different aspects of neuromuscular block this typical response was confirmed, but it was also noted that occasionally a...