acrylamide (aa) is an important industrial chemical agent that is mainly used in the production of polymers and copolymers. recently it has been attention because of its production in the diet at high-temperature (>120 ºc) processes such as cooking, frying, toasting, roasting or baking of high carbohydrate foods. according to high exposure to acrylamide, recognition of its toxic effect is neces...

Intrathecal treatment with methotrexate, an essential chemotherapeutic for both prophylaxis and treatment of central nervous system involvement of leukemia, may be associated with local neurotoxicity and/or systemic toxicity. Signs of acute neurotoxicity include confusion, disorientation, seizures, aphasia, ataxia, dysarthria, paresis and even paralysis. Presented here is a case of a 58 year ol...

Paclitaxel (Px) is an effective chemotherapeutic agent for the treatment of various cancers. However, it is often associated with neurological side effects, including chemotherapy-associated cognitive impairment (CACI), such as "chemobrain". Previously, we reported that endoplasmic reticulum (ER) stress is involved in Px-induced neurotoxicity, and immunoglobulin heavy chain binding protein (BiP...